Redox signalisation and functions of the Fe-S proteins


Cécile Bouton is a cell biologist and project leader at ICSN-CNRS. She has a 20-year experience in the field of Fe-S proteins including a strong expertise in the structure-function relationship of Iron regulatory Protein-1 (IRP1), a master regulator of cellular iron homeostasis. She joined the field of Fe-S biogenesis in mammals 15 years ago, establishing the crucial connection between mitochondria and the cytosolic compartment in mammalian Fe-S biogenesis. Her main research interest is focused on delineating the structure-function of Fe-S proteins as redox sensors through multidisciplinary and integrative research approaches. Recently, she has expanded her field of activity to translational programs combining (her) basic approaches and clinical research conducted by clinician scientists at Bicêtre Hospital (Kremlin-Bicêtre, France), and dedicated to human diseases with defect in maturation of lipoylated proteins and mitochondrial tRNA. Last year, she was awarded the seed funding for translational research project on “Sulfur metabolism and mitochondrial infantile liver disease due to mutation in TRMU gene” (Aviesan, ITMO-BCDE).

Marie-Pierre Golinelli is a CNRS Researcher (CR1). After graduating in Chemistry, she did a PhD in Biochemistry under the supervision of Dr J. Meyer (Grenoble) and started to study Fe-S proteins. After 2 years with Prof Sheila S David (U. of Utah, Fe-S protein involved in DNA repair, MutY) and 2 more years with Dr Stephen Hughes (National Cancer Institute, NIH, reverse transcriptase from retroviruses), she was recruited in 2001. She was studying aminoacyl tRNA synthetases and cellular traficking by combining biochemical approches with cellular biology. In 2013, she joined the ICSN. She looks at Fe-S proteins focusing more on the NEET family, proteins acting as redox switch in mammalian cells. Member of the SFBC, SFBBM, COST Fe-S and FrenchBIC. Fe-S et du FrenchBIC. (CV)

Sylvie Riquier Assistant Engineer in biological techniques. Her work experiences are from biochemistry of proteins, proteomics to cellular biology.


Myriam Salameh, Biochemist in first year of thesis on Fe-S proteins. After four years at the Lebanese University in Lebanon, she completed her second year of master at the ENSAIA-National School of Agronomy and Food Industries in Nancy, in sciences and processes of the food,of the Biomane master “Biotechnologies Microbiology Food Nutrition Environment”.



Thomas Michel, Assistant Engineer. Just after he graduated with a Bachelor’s degree in Bioindustry and Biotechnology at Paris-Sud University, he was recruited in the I2BC and ICSN laboratories to work on a project called PlasmoPrim. This project, funded by the ANR, aims to understand the mechanism of redox antimalarial agents blocking the transmission of the parasite to mosquitoes.