Olivon, F.; Retailleau, P.; Desrat, S.; Touboul, D.; Roussi, F.; Apel, C.; Litaudon, M., Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking. J. Nat. Prod. 2020, 83(10), 3069-3079.

Azziz, S.; Obaid, A.; Aowda, S.; Mhd Bakri, Y.; Majhool, A.; Ibraheem, R.; Aldulaimi, T.; Idris, H.; Chee Fah, W.; Awang, K.; Litaudon, M.; Abdullah, F., Secondary Metabolites from Leaves of Polyalthia lateriflora and Their Antimicrobial Activity. Int. J. Res. Pharm. Sci 2020, 11(3), 4353-435.

Mai, H. D. T.; Toan, T. P.; Huu, G. T.; Le, T. N.; Oanh, V. T. K.; Hang, N. T. M.; Thu, H. T.; Chau, V. M.; Litaudon, M.; Pham, V. C., New flavonoid and stilbene derivatives from the fruits of Macaranga balansae. Nat. Prod. Res. 2020, 34(19), 2772-2778.

Menguy, E.; Dumontet, V.; Coulombier, N.; Meriot, V.; Le Déan, L.; Barthelemy, V.; Jauffrais, T., A method to assess algicidal activity of microalgal extracts coupling microalgae produced in stirred closed photobioreactor operating in continuous with pulse amplitude modulated (PAM) fluorometry. MethodsX 2020, 7, 101037.

André, A.; Touré, A.K.; Stien, D.; Eparvier, V., 2,5-diketopiperazines mitigate the amount of advanced glycation end products accumulated with age in human dermal fibroblasts. Int. J. Cos. Sci. 2020, 42(6), 596-604.

Arias, M.H.; Quiliano, M.; Bourgeade-Delmas, S.; Fabing, I.; Chantal, I.; Berthier, D.; Minet, C.; Eparvier, V.; Sorres, J.; Stien, D.; Galiano, S.; Aldana, I.; Valentin, A.; Garavito, G.; Deharo E., Alsinol, an arylamino alcohol derivative active against PlasmodiumBabesiaTrypanosoma, and Leishmania: past and new outcomes. Parasitol. Res. 2020, 119, 3503–3515.

Barthélemy, M.; Guérineau, V.; Genta-Jouve, G.; Roy, M.; Chave, J.; Guillot, R.; Pellissier, L.; Wolfender, J-L.; Stien, D.; Eparvier, V.; Touboul, D., Identification and dereplication of endophytic Colletotrichum strains by MALDI TOF mass spectrometry and molecular networking. Sci. rep. 2020, 10, 19788.

Brel, O.; Touré, S.; Levasseur, M.; Lechat, C.; Pellissier, L.; Wolfender, J-L.; Van-Elslande, E.; Litaudon, M.; Dusfour, I.; Stien, D.; Eparvier, V., Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa. J. Nat. Prod. 2020 83(10), 2915-2922.

Falkowski, M.; Jahn-Oyac, A.; Odonne, G.; Flora, C.; Estevez, Y.; Touré, S.; Boulogne, I.; Robinson, J.C.; Béreau, D.; Petit, P.; Azam, D.; Coke, M.; Issaly, J.; Gaborit, P.; Stien, D.; Eparvier, V.; Dusfour, I.; Houël, E., Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana. Acta tropica 2020, 201, 105179.

Hebra, T.; Eparvier, V.; Touboul, D., Atmospheric pressure photoionization versus electrospray for the dereplication of highly conjugated natural products using molecular networks. J. Chrom. A 2020, 1630, 461533.

Hoang, T.P.T.; Barthélemy, M.; Lami, R.; Stien, D.; Eparvier, V.; Touboul, D., Annotation and quantification of N-acyl homoserine lactones implied in bacterial quorum sensing by supercritical-fluid chromatography coupled with high-resolution mass spectrometry. Anal. Bioanal. Chem. 2020, 412, 2261–2276.

Peyrat, L.A.; Eparvier, V.; Eydoux, C.; Guillemot, J-C.; Litaudon, M.; Stien, D., Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors. J. Nat. Prod. 2020, 83, 2330–2336.

Sorres, J.; André, A.; Van Elslande, E.; Stien, D.; Eparvier, V., Potent and Non-Cytotoxic Antibacterial Compounds Against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island. Molecules 2020, 35, 65.

Mai, P-Y.; Levasseur, M.; Buisson, D.; Touboul, D.; Eparvier, V., Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach. Plants 2020, 9, 47.

Belhadj, S.; Keskes, H.; Apel, C.; Roussi, F.; Litaudon, M.; Hentati, O.; Allouche, N., Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri. Chem. Biol. Interact. 2020, 109167.

De la Torre-Tarazona, H.E.; Jiménez, R.; Bueno, P.; Camarero, S.; Román, L.; Fernández-García, J.L.; Beltrán, M.; Nothias, L.F.; Cachet, X.; Paolini, J.; Litaudon, M.; Alcami, J.; Bedoya, L.M., 4-Deoxyphorbol inhibits HIV-1 infection in synergism with antiretroviral drugs and reactivates viral reservoirs through PKC/MEK activation synergizing with vorinostat. Biochem. Pharmacol. 2020, 177, 113937.

Péresse, T.; Kovacs, D; Subra, M.; Bigay, J.; Tsai, M.-C.; Polidori, J.; Gautier, R.; Desrat, S.; Fleuriot, L.; Debayle, D.; Litaudon, M.; Pham, V.-C.; Bignon, J.; Antonny, B.; Roussi, F.;Mesmin, B., Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor. J. Biol. Chem. 2020, 295 (13), 4277-4288.

Abu Bakar, M.H.; Lee, P.Y.; Azmi, M.N.; Lotfiamir, N.S.; Faris Mohamad, M.S.; Nor Shahril, N.S.; Shariff, K.A.; Ya’akob, H.; Awang, K.; Litaudon, M., In vitro anti-hyperglycemic, antioxidant activities and intestinal glucose uptake evaluation of Endiandra kingiana extracts. Biocatal. Agric. Biotechnol. 2020, 25, 101594.

Gapil Tiamas, S.; Daressy, F.; Abou Samra, A.; Bignon, J.; Steinmetz, V.; Litaudon, M.; Fourneau, C.; Hoong Leong, K.; Ariffin, A.; Awang, K.; Desrat, S.; Roussi, F., Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. Bioorg. Med. Chem. Lett. 2020, 30 (7), 127003.

Nguyen, L. H.; Vu, V. N.; Phi Thi, D.; Tran, V. H.; Litaudon, M.; Roussi, F.; Nguyen, V. H.; Chau, V. M.; Doan Thi Mai, H.; Pham, V. C., Cytotoxic lignans from fruits of Cleistanthus tonkinensis. Fitoterapia 2020, 140, 104432.


Donald, J.; Barthélemy, M.; Gazal, N.; Eveno, Y.; Manzi, S.; Eparvier, V.; Stien, D.; Roy, M., Tropical Palm Endophytes Exhibit Low Competitive Structuring When Assessed Using Co-occurrence and Antipathogen Activity Analysis. Front. For. Glob. Change. 2019, 2,86.

Huonga, D. T. M.; Vu, L. T. N.; The Anh, L.; Cuc, N. T.; Nhiem, N. X.; Tai, B. H.; Van Kiem, P.; Litaudon, M.; Dang Thach, T.; Van Minh, C.; Pham, V. C., Cytotoxic prenylated flavonoids from the leaves of Macaranga indica. Phytochem. Lett. 2019, 34, 39-42.

Remy, S.; Solis, D.; Silland, P.; Neyts, J.; Roussi, F.; Touboul, D.; Litaudon, M., Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa. Phytochemistry 2019, 167, 112101.

Vu, L. T. N.; Anh, L. T.; Cuc, N. T.; Nhiem, N. X.; Tai, B. H.; Van Kiem, P.; Litaudon, M.; Thach, T. D.; Van Minh, C.; Mai, H. D. T.; Van Cuong, P., Prenylated flavonoids and other constituents from Macaranga indica. Nat. Prod. Res. 2019, 1-8.

Le, T. N. V.; Truong, B. N.; Le, T. P.; Litaudon, M.; Tran, D. T.; Chau, V. M.; Mai, H. D. T.; Pham, V. C., Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata. Nat. Prod. Res. 2019, 1-8.

Lourteau, T.; Berriche, H.; Kécili, K.; Heim, V.; Bricault, D.; Litaudon, M.; Cachet, X.; Roussi, F.; Perrot, H.; Horner, O.; Cheap-Charpentier, H., Scale inhibition effect of Hylocereus undatus solution on calcium carbonate formation. J. Cryst. Growth 2019, 524, 125161

Fox Ramos, A. E.; Pavesi, C.; Litaudon, M.; Dumontet, V.; Poupon, E.; Champy, P.; Genta-Jouve, G.; Beniddir, M. A., CANPA: Computer-Assisted Natural Products Anticipation. Anal. Chem. 2019, 91 (17), 11247-11252

Remy, S.; Litaudon, M., Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication. Molecules 2019, 24 (12).

Nothias-Esposito, M.; Nothias, L. F.; Da Silva, R. R.; Retailleau, P.; Zhang, Z.; Leyssen, P.; Roussi, F.; Touboul, D.; Paolini, J.; Dorrestein, P. C.; Litaudon, M., Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation. J. Nat. Prod. 2019, 82 (6), 1459-1470.

Rodrigues, A. M. S.; Eparvier, V.; Odonne, G.; Amusant, N.; Stien, D.; Houël, E., The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci. Rep. 2019, 9 (1), 8729.

Barthélemy, M.; Elie, N.; Pellissier, L.; Wolfender, J.-L.; Stien, D.; Touboul, D.; Eparvier, V., Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach. Int. J. Mol. Sci. 2019, 20 (8), 2006.

Fox Ramos, A. E.; Le Pogam, P.; Fox Alcover, C.; Otogo N’Nang, E.; Cauchie, G.; Hazni, H.; Awang, K.; Bréard, D.; Echavarren, A. M.; Frédérich, M.; Gaslonde, T.; Girardot, M.; Grougnet, R.; Kirillova, M. S.; Kritsanida, M.; Lémus, C.; Le Ray, A.-M.; Lewin, G.; Litaudon, M.; Mambu, L.; Michel, S.; Miloserdov, F. M.; Muratore, M. E.; Richomme-Peniguel, P.; Roussi, F.; Evanno, L.; Poupon, E.; Champy, P.; Beniddir, M. A., Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research. Sci. Data 2019, 6 (1), 15.

Doan Thi Thuy, A.; Trinh Thi Thanh, V.; Doan Thi Mai, H.; Le, H. T.; Litaudon, M.; Nguyen, V. H.; Chau, V. M.; Pham, V. C., Cytotoxic Alkaloids from Leaves of Pilea aff. martinii. Planta Med. 2019, 85 (06), 496-502.

Obaid Aldulaimi, A. K.; Abdul Azziz, S. S. S.; Bakri, Y. M.; Nafiah, M. A.; Aowda, S. A.; Awang, K.; Litaudon, M., Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity. Phytochem. Lett. 2019, 29, 110-114.

Chong, S.-L.; Hematpoor, A.; Hazni, H.; Sofian-Azirun, M.; Litaudon, M.; Supratman, U.; Murata, M.; Awang, K., Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern. Phytochem. Lett. 2019, 30, 69-73.

Wolfender, J.-L.; Litaudon, M.; Touboul, D.; Queiroz, E. F., Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery. Nat. Prod. Rep. 2019, 36, 855-868.

Olivon, F.; Remy, S.; Grelier, G.; Apel, C.; Eydoux, C.; Guillemot, J.-C.; Neyts, J.; Delang, L.; Touboul, D.; Roussi, F.; Litaudon, M., Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach. J. Nat. Prod. 2019, 82 (2), 330-340.

Touré, S.; Desrat, S.; Pellissier, L.; Allard, P.-M.; Wolfender, J.-L.; Dusfour, I.; Stien, D.; Eparvier, V., Characterization, Diversity, and Structure-Activity Relationship Study of Lipoamino Acids from Pantoea sp. and Synthetic Analogues. Int. J. Mol. Sci. 2019, 20 (5), 1083.

Khoury, M.; El Beyrouthy, M.; Ouaini, N.; Eparvier, V.; Stien, D., Hirtellina lobelii DC. essential oil, its constituents, its combination with antimicrobial drugs and its mode of action. Fitoterapia 2019, 133, 130-136.


Touré, Seindé; Barthélémy, Morgane; Sorres, Jonathan; Genta-Jouve, Grégory; Dusfour, Isabelle; Eparvier, Véronique; Stien, Didier. Mucorolactone, a Macrolactone from Mucor sp. SNB-VECD13A, a Fungus Isolated from the Cuticle of a Vespidae Species. Org. Lett. 2018, 20 (13), 3780-3783.

Sorres, Jonathan; Sabri, Abir; Brel, Orianne; Stien, Didier; Eparvier, Véronique. Ilicicolinic acids and ilicicolinal derivatives from the fungus Neonectria discophora SNB-CN63 isolated from the nest of the termite Nasutitermes corniger found in French Guiana show antimicrobial activity. Phytochemistry 2018, 151, 69-77.

Nasr, Shaghayegh; Lutz, Matthias; Amoozegar, Mohammad Ali; Eparvier, Véronique; Stien, Didier; Fazeli, Seyed Abolhassan Shahzadeh; Yurkov, Andrey. Graphiola fimbriata: the first species of Graphiolaceae (Exobasidiales, Basidiomycota) described only based on its yeast stage. Mycological Progress 2018.

Khoury, Madona; El Beyrouthy, Marc; Eparvier, Véronique; Ouaini, Naïm; Stien, Didier. Chemical diversity and antimicrobial activity of the essential oils of four Apiaceae species growing wild in Lebanon. J. Essent. Oil Res. 2018, 30 (1), 25-31.

André, Amandine, Wdzieczak-Bakala, Joanna; Touré, Alexis Kaatio; Stien, Didier; Eparvier, Véronique. A method to quantify intracellular glycation in dermal fibroblasts using liquid chromatography coupled to fluorescence detection – Application to the selection of deglycation compounds of dermatological interest. J. Chromatogr. B 2018, 1100-1101, 100-105.

Trieu, Quy Hung; Mai, Huong Doan Thi; Litaudon, Marc; Phi Thi, Dao; Tran, Tuan Anh; Nguyen, Van Hung; Chau, Van Minh; Pham, Van Cuong. Two new linear acetogenins from the fruits of Goniothalamus gracilipes. Nat. Prod. Res. 2018, 32 (3), 287-293.

Tiamas Shelly, Gapil; Audet, Florian; Abou Samra, Alma; Bignon, Jérome; Litaudon, Marc; Fourneau, Christophe; Ariffin, Azhar; Awang, Khalijah; Desrat, Sandy; Roussi, Fanny. Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene‐Derived Cyclohexenyl Chalcones. Eur. J. Org. Chem. 2018,  (42), 5830-5835.

Thuy, Ai Doan Thi; Thanh, Van Trinh Thi; Mai, Huong Doan Thi; Le, Huyen Tram; Litaudon, Marc; Chau, Van Minh; Pham, Van Cuong. Pileamartines A and B: Alkaloids from Pilea aff. martinii with a new carbon skeleton. Tetrahedron Lett. 2018, 59 (20), 1909-1912.

Sulaiman, Syazreen Nadia; Zahari, Azeana; Liew, Sook Yee; Litaudon, Marc; Issam, A. M.; Wahab, Habibah A.; Awang, Khalijah. Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae). Phytochem. Lett. 2018, 25, 22-26.

Remy, Simon; Olivon, Florent; Desrat, Sandy; Blanchard, Florent; Eparvier, Véronique; Leyssen, Pieter; Neyts, Johan; Roussi, Fanny; Touboul, David; Litaudon, Marc. Structurally Diverse Diterpenoids from Sandwithia guyanensis. J. Nat. Prod. 2018, 81 (4), 901-912.

Remeur, Camille, Desrat, Sandy; Gandon, Vincent; Roussi, Fanny. Selectivity in the Intermolecular Diels–Alder Reaction of Conjugated Trienes: Experimental and Theoretical Approaches. Eur. J. Org. Chem. 2018,  (42), 5869-5877.

Olivon, Florent, Nothias, Louis-Félix; Dumontet, Vincent; Retailleau, Pascal; Berger, Sylvie; Ferry, Gilles; Cohen, William; Pfeiffer, Bruno; Boutin, Jean A.; Scalbert, Elisabeth; Roussi, Fanny; Litaudon, Marc. Natural Inhibitors of the RhoA–p115 Complex from the Bark of Meiogyne baillonii. J. Nat. Prod. 2018, 81 (7), 1610-1618.

Olivon, Florent; Elie, Nicolas; Grelier, Gwendal; Roussi, Fanny; Litaudon, Marc; Touboul, David. MetGem software for the generation of molecular networks based on t-SNE algorithm. Anal. Chem. 2018, 90 (23), 13900-13908.

Olivon, Florent; Apel, Cécile; Retailleau, Pascal; Allard, Pierre-Marie; Wolfender, Jean-Luc; Touboul, David; Roussi, Fanny; Litaudon, Marc; Desrat, Sandy. Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines. Org. Chem. Front. 2018, 5 (14), 2171-2178.

Nothias, Louis-Félix; Nothias-Esposito, Mélissa; da Silva, Ricardo; Wang, Mingxun; Protsyuk, Ivan; Zhang, Zheng; Sarvepalli, Abi; Leyssen, Pieter; Touboul, David; Costa, Jean; Paolini, Julien; Alexandrov, Theodore; Litaudon, Marc; Dorrestein, Pieter C.. Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. J. Nat. Prod. 2018, 81 (4), 758-767.

Nothias, Louis-Félix; Ballero, Mauro; Maxia, Andrea; Pollastro, Federica; Dorrestein, Pieter; Paolini, Julien; Litaudon, Marc; Appendino, Giovanni. Recherche du vrai profil phytochimique de Ferula arrigonii Bocchieri. Phytochimie 2018, 1 (Numéro 1).

Ledoux, Allison; Cao, Martine; Jansen, Olivia; Lucia, Mamede; Campos, Pierre-Eric; Payet, Bertrand; Clerc, Patricia; Grondin, Isabelle; Girard-Valenciennes, Emmanuelle; Hermann, Thomas; Litaudon, Marc; Vanderheydt, Charlotte; Delang, Leen; Neyts, Johan; Leyssen, Pieter; Frédérich, Michel; Smadja, Jacqueline. Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands. Int. J. Antimicrob. Agents 2018, 52 (5), 622-628.

Khazem, Mays; Jolly, Claire; Gaslonde, Thomas; Massip, Stéphane; Negrier, Philippe; Espeau, Philippe; Michel, Sylvie; Litaudon, Marc. Spirokermeline, a new macrocyclic spirolactone from Kermadecia elliptica Brongn. & Gris. Eur. J. Org. Chem. 2018,  (42), 5819-5822.

Apel, Cécile: Bignon, Jérôme; Garcia-Alvarez, María Concepción; Ciccone, Sarah; Clerc, Patricia; Grondin, Isabelle; Girard-Valenciennes, Emmanuelle; Smadja, Jacqueline; Lopes, Philippe; Frédérich, Michel; Roussi, Fanny; Meinnel, Thierry; Giglione, Carmela; Litaudon, Marc. N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë. Fitoterapia 2018, 131, 91-95.

Abou Samra, Alma; Robert, Aude; Gov, Crystal; Favre, Loëtitia; Eloy, Laure; Jacquet, Eric; Bignon, Jérôme; Wiels, Joëlle; Desrat, Sandy; Roussi, Fanny. Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur. J. Med. Chem. 2018, 148, 26-38