Paysant, H.; Hedir, S.; Justaud, F.; Weiswald, LB.; El Dine, AN.; Soulieman, A.; Hachem, A.; Elie, N.; Brotin, E.; Denoyelle, C.; Bignon, J.; Roussi, F.; Jouanne, M.; Tasseau, O.; Roisnel, T.; Voisin-Chiret, AS.; Gree, R.; Levoin, N.; Poulain, L., Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues. Org. Biomol. Chem. 2021, 19 (41), 8968-8987.

Trieu, QH.; Pham, VC.; Retailleau, P.; Nguyen, V.; Litaudon, M.; Doan, TMH., Rare flavonoids and sesquiterpenoids isolated from the leaves of Goniothalamus gracilipes. Fitoterapia 2021, 155.

Thu, HNT.; Minh, QP.; Van, CP.; Van, TN.; Van, KP.; Thanh, TN.; Tu, ALT.; Litaudon, M.; The, SN., Cytotoxic and alpha-Glucosidase Inhibitory Xanthones from Garcinia mckeaniana Leaves and Molecular Docking Study. Chem. Biodivers. 2021, OCT 2021.

Azmi, MN.; Saad, NA.; Abu Bakar, MH.; Omar, MTC.; Aziz, AN.; Wahab, HA.; Siddiq, S.; Choudhary, MI.; Litaudon, M.; Awang, K., Cyclic Polyketides with alpha-Glucosidase Inhibitory Activity from Endiandra kingiana Gamble and Molecular Docking Study. Rec. Nat. Prod. 2021, 15 (5), 414-419.

Kouame, T.; Bernadat, G.; Turpin, V.; Litaudon, M.; Okpekon, AT.; Gallard, JF.; Leblanc, K.; Rharrabti, S.; Champy, P.; Poupon, E., Structure Reassignment of Melonine and Quantum-Chemical Calculations-Based Assessment of Biosynthetic Scenarios Leading to Its Revised and Original Structures. Org. Lett. 2021, 23 (15), 5964-5968.

Cardone, C.; Caseau, CM.; Bardiaux, B.; Thureaux, A.; Galloux, M.; Bajorek, M.; Eleouet, JF.; Litaudon, M.; Bontems, F.; Sizun, C., A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein. Biomolecules 2021, 11 (8), 1225.

Ha, NTT.; Tuyen, NV.; Tra, NT.; Anh, LTT.; Son, NT.; Litaudon, M., Cuong, PV.; Tai, BH.; Kiem, PV., Garcimckeans A-C, three new xanthones from the stems of Garcinia mckeaniana, and their cytotoxic activity. Nat. Prod. Res. 2021, JUL 2021.

Nguyen, TTH.; Nguyen, V.; Cuong, VP.; Thanh, TN.; Thi, TAL.; Huong, DTM.; Truong, BN.; Litaudon, M.; The, SN., A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities. Nat. Prod. Res. 2021, APR 2021.

Daressy, F.; Malard, F.; Seguy, L.; Guerineau, V.; Apel, C.; Dumontet, V.; Robert, A.; Groo, AC.; Litaudon, M.; Bignon, J.; Desrat, S.; Malzert-Freon, A.; Wiels, J.; Lescop, E.; Roussi, F., Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1. ChemMedChem 2021, 16 (11), 1788-1797.

Levaique, H.; Pamlard, O.; Apel, C.; Bignon, J.; Arriola, M.; Kuhner, R.; Awang, K.; Loiseau, PM.; Litaudon, M.; Pomel, S., Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities. Molecules 2021, 26 (6), 1551.

Tra, NT.; Son, NT.; Tuyen, NV.; Cuong, PV.; Ha, NTT.; Anh, LTT.; Huong, DTM.; Ngan, TB.; Litaudon, M., A new cytotoxic compound from the leaves of Styrax annamensis Guillaumin. Nat. Prod. Res. 2021, FEB 2021.


Olivon, F.; Retailleau, P.; Desrat, S.; Touboul, D.; Roussi, F.; Apel, C.; Litaudon, M., Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking. J. Nat. Prod. 2020, 83(10), 3069-3079.

Azziz, S.; Obaid, A.; Aowda, S.; Mhd Bakri, Y.; Majhool, A.; Ibraheem, R.; Aldulaimi, T.; Idris, H.; Chee Fah, W.; Awang, K.; Litaudon, M.; Abdullah, F., Secondary Metabolites from Leaves of Polyalthia lateriflora and Their Antimicrobial Activity. Int. J. Res. Pharm. Sci 2020, 11(3), 4353-435.

Mai, H. D. T.; Toan, T. P.; Huu, G. T.; Le, T. N.; Oanh, V. T. K.; Hang, N. T. M.; Thu, H. T.; Chau, V. M.; Litaudon, M.; Pham, V. C., New flavonoid and stilbene derivatives from the fruits of Macaranga balansae. Nat. Prod. Res. 2020, 34(19), 2772-2778.

Menguy, E.; Dumontet, V.; Coulombier, N.; Meriot, V.; Le Déan, L.; Barthelemy, V.; Jauffrais, T., A method to assess algicidal activity of microalgal extracts coupling microalgae produced in stirred closed photobioreactor operating in continuous with pulse amplitude modulated (PAM) fluorometry. MethodsX 2020, 7, 101037.

Brel, O.; Touré, S.; Levasseur, M.; Lechat, C.; Pellissier, L.; Wolfender, J-L.; Van-Elslande, E.; Litaudon, M.; Dusfour, I.; Stien, D.; Eparvier, V., Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa. J. Nat. Prod. 2020 83(10), 2915-2922.

Peyrat, L.A.; Eparvier, V.; Eydoux, C.; Guillemot, J-C.; Litaudon, M.; Stien, D., Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors. J. Nat. Prod. 2020, 83, 2330–2336.

Belhadj, S.; Keskes, H.; Apel, C.; Roussi, F.; Litaudon, M.; Hentati, O.; Allouche, N., Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri. Chem. Biol. Interact. 2020, 109167.

De la Torre-Tarazona, H.E.; Jiménez, R.; Bueno, P.; Camarero, S.; Román, L.; Fernández-García, J.L.; Beltrán, M.; Nothias, L.F.; Cachet, X.; Paolini, J.; Litaudon, M.; Alcami, J.; Bedoya, L.M., 4-Deoxyphorbol inhibits HIV-1 infection in synergism with antiretroviral drugs and reactivates viral reservoirs through PKC/MEK activation synergizing with vorinostat. Biochem. Pharmacol. 2020, 177, 113937.

Péresse, T.; Kovacs, D; Subra, M.; Bigay, J.; Tsai, M.-C.; Polidori, J.; Gautier, R.; Desrat, S.; Fleuriot, L.; Debayle, D.; Litaudon, M.; Pham, V.-C.; Bignon, J.; Antonny, B.; Roussi, F.;Mesmin, B., Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor. J. Biol. Chem. 2020, 295 (13), 4277-4288.

Abu Bakar, M.H.; Lee, P.Y.; Azmi, M.N.; Lotfiamir, N.S.; Faris Mohamad, M.S.; Nor Shahril, N.S.; Shariff, K.A.; Ya’akob, H.; Awang, K.; Litaudon, M., In vitro anti-hyperglycemic, antioxidant activities and intestinal glucose uptake evaluation of Endiandra kingiana extracts. Biocatal. Agric. Biotechnol. 2020, 25, 101594.

Gapil Tiamas, S.; Daressy, F.; Abou Samra, A.; Bignon, J.; Steinmetz, V.; Litaudon, M.; Fourneau, C.; Hoong Leong, K.; Ariffin, A.; Awang, K.; Desrat, S.; Roussi, F., Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. Bioorg. Med. Chem. Lett. 2020, 30 (7), 127003.

Nguyen, L. H.; Vu, V. N.; Phi Thi, D.; Tran, V. H.; Litaudon, M.; Roussi, F.; Nguyen, V. H.; Chau, V. M.; Doan Thi Mai, H.; Pham, V. C., Cytotoxic lignans from fruits of Cleistanthus tonkinensis. Fitoterapia 2020, 140, 104432.


Huonga, D. T. M.; Vu, L. T. N.; The Anh, L.; Cuc, N. T.; Nhiem, N. X.; Tai, B. H.; Van Kiem, P.; Litaudon, M.; Dang Thach, T.; Van Minh, C.; Pham, V. C., Cytotoxic prenylated flavonoids from the leaves of Macaranga indica. Phytochem. Lett. 2019, 34, 39-42.

Remy, S.; Solis, D.; Silland, P.; Neyts, J.; Roussi, F.; Touboul, D.; Litaudon, M., Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa. Phytochemistry 2019, 167, 112101.

Vu, L. T. N.; Anh, L. T.; Cuc, N. T.; Nhiem, N. X.; Tai, B. H.; Van Kiem, P.; Litaudon, M.; Thach, T. D.; Van Minh, C.; Mai, H. D. T.; Van Cuong, P., Prenylated flavonoids and other constituents from Macaranga indica. Nat. Prod. Res. 2019, 1-8.

Le, T. N. V.; Truong, B. N.; Le, T. P.; Litaudon, M.; Tran, D. T.; Chau, V. M.; Mai, H. D. T.; Pham, V. C., Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata. Nat. Prod. Res. 2019, 1-8.

Lourteau, T.; Berriche, H.; Kécili, K.; Heim, V.; Bricault, D.; Litaudon, M.; Cachet, X.; Roussi, F.; Perrot, H.; Horner, O.; Cheap-Charpentier, H., Scale inhibition effect of Hylocereus undatus solution on calcium carbonate formation. J. Cryst. Growth 2019, 524, 125161

Fox Ramos, A. E.; Pavesi, C.; Litaudon, M.; Dumontet, V.; Poupon, E.; Champy, P.; Genta-Jouve, G.; Beniddir, M. A., CANPA: Computer-Assisted Natural Products Anticipation. Anal. Chem. 2019, 91 (17), 11247-11252

Remy, S.; Litaudon, M., Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication. Molecules 2019, 24 (12).

Nothias-Esposito, M.; Nothias, L. F.; Da Silva, R. R.; Retailleau, P.; Zhang, Z.; Leyssen, P.; Roussi, F.; Touboul, D.; Paolini, J.; Dorrestein, P. C.; Litaudon, M., Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation. J. Nat. Prod. 2019, 82 (6), 1459-1470.

Fox Ramos, A. E.; Le Pogam, P.; Fox Alcover, C.; Otogo N’Nang, E.; Cauchie, G.; Hazni, H.; Awang, K.; Bréard, D.; Echavarren, A. M.; Frédérich, M.; Gaslonde, T.; Girardot, M.; Grougnet, R.; Kirillova, M. S.; Kritsanida, M.; Lémus, C.; Le Ray, A.-M.; Lewin, G.; Litaudon, M.; Mambu, L.; Michel, S.; Miloserdov, F. M.; Muratore, M. E.; Richomme-Peniguel, P.; Roussi, F.; Evanno, L.; Poupon, E.; Champy, P.; Beniddir, M. A., Collected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research. Sci. Data 2019, 6 (1), 15.

Doan Thi Thuy, A.; Trinh Thi Thanh, V.; Doan Thi Mai, H.; Le, H. T.; Litaudon, M.; Nguyen, V. H.; Chau, V. M.; Pham, V. C., Cytotoxic Alkaloids from Leaves of Pilea aff. martinii. Planta Med. 2019, 85 (06), 496-502.

Obaid Aldulaimi, A. K.; Abdul Azziz, S. S. S.; Bakri, Y. M.; Nafiah, M. A.; Aowda, S. A.; Awang, K.; Litaudon, M., Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity. Phytochem. Lett. 2019, 29, 110-114.

Chong, S.-L.; Hematpoor, A.; Hazni, H.; Sofian-Azirun, M.; Litaudon, M.; Supratman, U.; Murata, M.; Awang, K., Mosquito larvicidal limonoids from the fruits of Chisocheton erythrocarpus Hiern. Phytochem. Lett. 2019, 30, 69-73.

Wolfender, J.-L.; Litaudon, M.; Touboul, D.; Queiroz, E. F., Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discovery. Nat. Prod. Rep. 2019, 36, 855-868.

Olivon, F.; Remy, S.; Grelier, G.; Apel, C.; Eydoux, C.; Guillemot, J.-C.; Neyts, J.; Delang, L.; Touboul, D.; Roussi, F.; Litaudon, M., Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach. J. Nat. Prod. 2019, 82 (2), 330-340.

Touré, S.; Desrat, S.; Pellissier, L.; Allard, P.-M.; Wolfender, J.-L.; Dusfour, I.; Stien, D.; Eparvier, V., Characterization, Diversity, and Structure-Activity Relationship Study of Lipoamino Acids from Pantoea sp. and Synthetic Analogues. Int. J. Mol. Sci. 2019, 20 (5), 1083.


Trieu, Quy Hung; Mai, Huong Doan Thi; Litaudon, Marc; Phi Thi, Dao; Tran, Tuan Anh; Nguyen, Van Hung; Chau, Van Minh; Pham, Van Cuong. Two new linear acetogenins from the fruits of Goniothalamus gracilipes. Nat. Prod. Res. 2018, 32 (3), 287-293.

Tiamas Shelly, Gapil; Audet, Florian; Abou Samra, Alma; Bignon, Jérome; Litaudon, Marc; Fourneau, Christophe; Ariffin, Azhar; Awang, Khalijah; Desrat, Sandy; Roussi, Fanny. Asymmetric Total Synthesis and Biological Evaluation of Proapoptotic Natural Myrcene‐Derived Cyclohexenyl Chalcones. Eur. J. Org. Chem. 2018,  (42), 5830-5835.

Thuy, Ai Doan Thi; Thanh, Van Trinh Thi; Mai, Huong Doan Thi; Le, Huyen Tram; Litaudon, Marc; Chau, Van Minh; Pham, Van Cuong. Pileamartines A and B: Alkaloids from Pilea aff. martinii with a new carbon skeleton. Tetrahedron Lett. 2018, 59 (20), 1909-1912.

Sulaiman, Syazreen Nadia; Zahari, Azeana; Liew, Sook Yee; Litaudon, Marc; Issam, A. M.; Wahab, Habibah A.; Awang, Khalijah. Pahangine A and B, two new oxetane containing neolignans from the barks of Beilschmiedia glabra Kosterm (Lauraceae). Phytochem. Lett. 2018, 25, 22-26.

Remy, Simon; Olivon, Florent; Desrat, Sandy; Blanchard, Florent; Eparvier, Véronique; Leyssen, Pieter; Neyts, Johan; Roussi, Fanny; Touboul, David; Litaudon, Marc. Structurally Diverse Diterpenoids from Sandwithia guyanensis. J. Nat. Prod. 2018, 81 (4), 901-912.

Remeur, Camille, Desrat, Sandy; Gandon, Vincent; Roussi, Fanny. Selectivity in the Intermolecular Diels–Alder Reaction of Conjugated Trienes: Experimental and Theoretical Approaches. Eur. J. Org. Chem. 2018,  (42), 5869-5877.

Olivon, Florent, Nothias, Louis-Félix; Dumontet, Vincent; Retailleau, Pascal; Berger, Sylvie; Ferry, Gilles; Cohen, William; Pfeiffer, Bruno; Boutin, Jean A.; Scalbert, Elisabeth; Roussi, Fanny; Litaudon, Marc. Natural Inhibitors of the RhoA–p115 Complex from the Bark of Meiogyne baillonii. J. Nat. Prod. 2018, 81 (7), 1610-1618.

Olivon, Florent; Elie, Nicolas; Grelier, Gwendal; Roussi, Fanny; Litaudon, Marc; Touboul, David. MetGem software for the generation of molecular networks based on t-SNE algorithm. Anal. Chem. 2018, 90 (23), 13900-13908.

Olivon, Florent; Apel, Cécile; Retailleau, Pascal; Allard, Pierre-Marie; Wolfender, Jean-Luc; Touboul, David; Roussi, Fanny; Litaudon, Marc; Desrat, Sandy. Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines. Org. Chem. Front. 2018, 5 (14), 2171-2178.

Nothias, Louis-Félix; Nothias-Esposito, Mélissa; da Silva, Ricardo; Wang, Mingxun; Protsyuk, Ivan; Zhang, Zheng; Sarvepalli, Abi; Leyssen, Pieter; Touboul, David; Costa, Jean; Paolini, Julien; Alexandrov, Theodore; Litaudon, Marc; Dorrestein, Pieter C.. Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. J. Nat. Prod. 2018, 81 (4), 758-767.

Nothias, Louis-Félix; Ballero, Mauro; Maxia, Andrea; Pollastro, Federica; Dorrestein, Pieter; Paolini, Julien; Litaudon, Marc; Appendino, Giovanni. Recherche du vrai profil phytochimique de Ferula arrigonii Bocchieri. Phytochimie 2018, 1 (Numéro 1).

Ledoux, Allison; Cao, Martine; Jansen, Olivia; Lucia, Mamede; Campos, Pierre-Eric; Payet, Bertrand; Clerc, Patricia; Grondin, Isabelle; Girard-Valenciennes, Emmanuelle; Hermann, Thomas; Litaudon, Marc; Vanderheydt, Charlotte; Delang, Leen; Neyts, Johan; Leyssen, Pieter; Frédérich, Michel; Smadja, Jacqueline. Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands. Int. J. Antimicrob. Agents 2018, 52 (5), 622-628.

Khazem, Mays; Jolly, Claire; Gaslonde, Thomas; Massip, Stéphane; Negrier, Philippe; Espeau, Philippe; Michel, Sylvie; Litaudon, Marc. Spirokermeline, a new macrocyclic spirolactone from Kermadecia elliptica Brongn. & Gris. Eur. J. Org. Chem. 2018,  (42), 5819-5822.

Apel, Cécile: Bignon, Jérôme; Garcia-Alvarez, María Concepción; Ciccone, Sarah; Clerc, Patricia; Grondin, Isabelle; Girard-Valenciennes, Emmanuelle; Smadja, Jacqueline; Lopes, Philippe; Frédérich, Michel; Roussi, Fanny; Meinnel, Thierry; Giglione, Carmela; Litaudon, Marc. N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë. Fitoterapia 2018, 131, 91-95.

Abou Samra, Alma; Robert, Aude; Gov, Crystal; Favre, Loëtitia; Eloy, Laure; Jacquet, Eric; Bignon, Jérôme; Wiels, Joëlle; Desrat, Sandy; Roussi, Fanny. Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur. J. Med. Chem. 2018, 148, 26-38