Improving surveillance of antibiotic-resistant Pseudomonas aeruginosa in Europe
- Funding : Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Network
- Duration : 2023-2024
- Coordinator : Antonio Oliver (Hospital Universitari Son Espases-IdISBa, Palma de Mallorca, Spain)
- Partners : Jesús Oteo Iglesias (Instituto de Salud Carlos III, Madrid, Spain), Laurent Poirel (University of Fribourg, Switzerland), Tomislav Kostyanev (Laboratoire national de santé, Luxembourg), Peter Croughs (Erasmus Medical Center, Rotterdam, Netherlands), Bogdan I. Iorga (ICSN), Arnfinn Sundsfjord (Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Norway), Annarita Mazzariol (University of Verona, Italy), Andreas Kronenberg (Swiss Antibiotic Resistance Centre ANRESIS, Switzerland), Patricia Alexandra Curado Quintas Diniz Poeta (University of Trás-os-Montes and Alto Douro, Portugal), Dóra Szabó (Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary), Tíscar Graells (Royal Swedish Academy of Sciences, Sweden), Arjana Tambić Andrašević (University Hospital for Infectious Diseases, Zagreb, Croatia), Mateja Pirs (University of Ljubljana, Slovenia), Rossitza Vatcheva-Dobrevska (University Hospital ‘Queen Joanna’, Sofia, Bulgary), Astra Vitkauskienė (Lithuanian University of Health Sciences, Kaunas, Lithuania), Olivier Denis (CHU UCL Namur, Belgium), Rafael Cantón Moreno (Complutense University, Madrid, Spain), Luis Martínez Martínez (University of Córdoba, Spain), Cansu Cimen (University of Oldenburg, Germany), Yeşim Beşli (VKV American Hospital, Istanbul, Turkey), Thierry Naas (Université Paris-Saclay, Bicêtre, France), Christian Giske (Karolinska Institutet, Stockholm, Sweden), Jorge Arca Suárez (Complexo Hospitalario Universitario A Coruña, Spain), Onur Karatuna (EUCAST Development Laboratory, Växjö, Sweden), Surbhi Malhotra-Kumar (University of Antwerp, Belgium)
Whole genome sequencing and artificial intelligence to characterise and diagnose antibiotic resistance and capacity to escape treatment
- Funding : Agence Nationale de la Recherche (ANR), PPR Antibiorésistance
- Duration : 2021-2026
- Coordinator : Philippe Glaser (Institut Pasteur, Paris)
- Partners : Flora Jay (Université Paris-Saclay, Orsay), Thierry Naas (Université Paris-Saclay, Bicêtre), Bogdan I. Iorga (ICSN), Grégory Batt (INRIA & Institut Pasteur, Paris), Nicolas Grégoire (Faculté de Médecine et Pharmacie, Poitiers), Patrick Plésiat (Université de Franche-Comté, Besançon), Olivier Barraud (Faculté de Médecine, Limoges), Jean-Yves Madec (ANSES, Lyon)
Exploration of Pipelines for Inhibitors of Carbapenemases (EPIC Alliance)
- Funding : Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) Network Plus
- Duration : 2021-2023
- Coordinator : Elias Dahdouh (Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, Spain)
- Partners : Jesús Mingorance Cruz (Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, Spain), Paulino Gómez Puertas (Centro de Biologia Molecular, CBMSO, CSIC-UAM, Spain), Stefano Lorenzetti (Istituto Superiore di Sanità, ISS, Italy), Thierry Naas (Université Paris-Saclay, Hôpital de Bicêtre, France), Bogdan I. Iorga (ICSN), Nathaniel Martin (Institute of Biology Leiden, Netherlands), Joe Rubin (University of Saskatchewan at Saskatoon, Canada), Luis Martínez-Martínez (Instituto Maimónides de Investigación Biomédica de Córdoba, IMIBIC, Spain), Thomas Tängdén (Uppsala University, Sweden), Linda Falgenhauer (Justus Liebig University Giessen, Germany)
Fluorinated Ligands Approach for the Inhibition of Rotamases (F-LAIR)
- Funding : Agence Nationale de la Recherche (ANR)
- Duration : 2018-2023
- Coordinator : Thierry Brigaud (Université Cergy-Pontoise, France)
- Partners : Emeric Miclet (LBM, UPMC, Paris), Bogdan I. Iorga (ICSN)
Innovative protocols to meet the challenges of prediction in molecular modelling
- Funding : Globetalkers 2019, Université Paris-Saclay
- Duration : 2019-2020
- Coordinator : Bogdan I. Iorga (ICSN)
Development of carbapenemase inhibitors for fighting antibiotic resistance (CARBAMAT)
- Funding : SATT Paris-Saclay, AAP Maturation
- Duration : 2016-2018
- Coordinator : Thierry Naas (Université Paris-Sud, Bicêtre, France)
- Partners : Bogdan I. Iorga (ICSN), Robert H. Dodd (ICSN), Jean-Christophe Cintrat (DRF/IBITECS-SCBM, CEA Saclay, France), Alain Pruvost (DRF/IBITECS-SPI, CEA Saclay, France)
Optimisation of a new class of carbapenemase inhibitors active against resistant strains (INHIBASE)
- Funding : IDEX Paris-Saclay, AAP Pre-maturation
- Duration : 2015-2016
- Coordinator : Thierry Naas (Université Paris-Sud, Bicêtre, France)
- Partners : Robert H. Dodd (ICSN), Bogdan I. Iorga (ICSN)
Structure-guided design of pan-inhibitors of metallo-β-lactamases (DesInMBL)
- Funding : Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)
- Duration : 2015-2018
- Coordinator : Thierry Naas (Université Paris-Sud, Bicêtre, France)
- Partners : Youri Glupczynski (Université catholique de Louvain, Mont-Goddine, Belgique), Bogdan I. Iorga (ICSN), Mariusz Jaskólski (Institut de Chimie Bioorganique, Académie Polonaise de Sciences, Poznań, Pologne), Laurent Salmon (LCBB, ICMMO, Université Paris-Sud, Orsay, France)
Study of interaction mode and optimisation of a new class of carbapenemase inhibitors active against classes A, B, and D
- Funding : Région Ile-de-France, DIM Maladies Infectieuses
- Duration : 2015-2018
- Coordinator : Thierry Naas (Université Paris-Sud, Bicêtre, France)
- Partners : Robert H. Dodd (ICSN), Bogdan I. Iorga (ICSN)
Inhibitors targeting carbapenemases for fighting antibiotic-resistant Gram-negative bacteria
- Funding : Laboratoire d’Excellence en Recherche sur le Médicament et l’Innovation Thérapeutique (LabEx LERMIT)
- Duration : 2012-2019
- Coordinators : Thierry Naas (Université Paris-Sud, Bicêtre, France), Bogdan I. Iorga (ICSN)
- Partners : Robert H. Dodd (ICSN), Eric Guittet (ICSN), Sandrine Ongeri & Benoît Crousse (BioCIS, Université Paris-Sud, Châtenay-Malabry, France), Laurent Salmon (LCBB, ICMMO, Université Paris-Sud, Orsay, France), Jean-Christophe Cintrat (DRF/IBITECS-SCBM, CEA Saclay, France), Alain Pruvost (DRF/IBITECS-SPI, CEA Saclay, France)
New therapeutic targets to treat cardiovascular diseases
- Funding : Laboratoire d’Excellence en Recherche sur le Médicament et l’Innovation Thérapeutique (LabEx LERMIT)
- Duration : 2012-2017
- Coordinators : Rodolphe Fischmeister (Université Paris-Sud, Châtenay-Malabry, France), Yves Ambroise (DRF/IBITECS-SCBM, CEA Saclay, France)
- Partners : Bogdan I. Iorga (ICSN), Alain Pruvost (DRF/IBITECS-SPI, CEA Saclay, France), Jacqueline Cherfils (LBPA, ENS Cachan, France)
Rational synthesis of compounds derived from a natural product, targeting two antiapoptotic proteins (APOMEIOA)
- Funding : Agence Nationale de la Recherche (ANR) JCJC
- Duration : 2010-2014
- Coordinator : Fanny Roussi (ICSN)
- Partners : Bogdan I. Iorga (ICSN), Eric Guittet (ICSN)
New chemistries of sialic acid targeting the flu virus (SIALIFLU)
- Funding : Agence Nationale de la Recherche (ANR)
- Duration : 2010-2013
- Coordinator : Jean-Marie Beau (LSB, ICMMO, Université Paris-Sud, Orsay, France)
- Partners : Bogdan I. Iorga (ICSN), Rupert Russell (BSRC, University of St. Andrews, Royaume-Uni)
Inhibition of human glucosamine-6P synthase for the treatment of complications associated with diabetes (GFATINIB)
- Funding : Agence Nationale de la Recherche (ANR)
- Duration : 2009-2012
- Coordinator : Marie-Ange Badet-Denisot (ICSN)
- Partners : Bogdan I. Iorga (ICSN), Michel Desmadril (Protein Engineering and Modeling, I2BC, Orsay, France), Fabienne Foufelle (Centre de Recherche des Cordeliers, INSERM, Paris, France)
Chemistry and pharmacology of gymnodimines, spirolides and their analogues (NEUROSPIROIMINE)
- Funding : Agence Nationale de la Recherche (ANR)
- Duration : 2007-2010
- Coordinator : Jordi Molgó (Institut de Neurobiologie Alfred Fessard, INAF, CNRS, Gif-sur-Yvette, France)
- Partners : Catherine Guillou, Bogdan I. Iorga (ICSN)
Modelling the open state of an ionotropic glutamate receptor
- Funding : European Commission, HPC Europa2 Transnational Access
- Duration : 2011
- Host partner for receiving Ranjit Vijayan, post-doctoral fellow at the University of Oxford
Calculation of free energies of substrate binding to cation-substrate membrane transport proteins widespread in nature
- Funding : European Commission, HPC Europa2 Transnational Access
- Duration : 2010
- Host partner for receiving Oliver Beckstein, post-doctoral fellow at the University of Oxford