Our pluridisciplinary objectives are bioinspired from the fascinating chemistry of Natural Products. We are working on four main Axes of Research:
- New Bioactive substances from Marine Organisms
- Biomechanistic Analysis and Biosynthetic pathways of Natural Products
- Biomimetic and Total Synthesis
- Medicinal Chemistry
Our group is interested in the isolation, synthesis and biological properties of novel marine substances that may be useful as drug leads for treatment of human disease. We have recently discovered new synthetic but naturally inspired derivatives targeting necroptotic and apoptotic programed cell death (PCD). The regulation of PCD pathways could have several applications in fighting cancer pathologies and inflammatory disorders (ischemic brain damage, myocardial ischemia…).