CV M-E. Huang

Dr. Meng Er Huang is a Research Director at the CNRS. During his early career as hematologist in Shanghai (China), he made a key contribution to the discovery of therapeutic effect of all-trans retinoic acid in the treatment of acute promyelocytic leukemia through induction of differentiation. In 1993, he obtained a PhD degree from the Université Paris-Diderot under the supervision of Dr. Francis Galibert. After a postdoctoral training, he joined CNRS as a junior researcher in 1995. From 2002 to 2005, he worked as a visiting scientist in the laboratory of Prof. Richard Kolodner at Ludwig Institute for Cancer Research at San Diego (California). Supported by a CNRS ATIP program in 2005, he created a new research team in the Institut Curie and led the research projects for better understand oxidative stress-induced genome instability and cell death, and redox-based mechanisms of anticancer molecules. He has joined the ICSN since 2020 in order to constitute a strong group that work on several aspects of redox biology. In this new scientific environment, he is continuously focusing on exploiting oxidative stress- and redox-based anticancer therapeutic strategy in leukemia, breast and lung cancer models.

Current main interests:

oxidative stress- and redox-based anticancer therapeutic strategy in leukemia, breast and lung cancer models; concepts, mechanisms and preclinical studies.

57 peer-reviewed publications, 1 book chapter, 1 patent

About 40 scientific communications at scientific conferences (invited speakers, oral communications and posters)

Complete List of publications 

  1. Huang ME, Ye JC, Chen SR, Zhao JC, Gu LJ, Cai JR, Zhao L, Xie JX, Shen ZX, Wang ZY (1987). [Treatment of acute promyelocytic leukemia by retinoic acid with or without low dose cytosine arabinoside: report of 4 cases]. Chinese Journal of Internal Medicine (Traduction en PubMed: Zhonghua Nei Ke Za Zhi) 26 : 330–332, 380.
  2. Huang ME, Ye JC, Chen SR, Zhao JC, Gu LJ, Cai JR, Zhao L, Xie JX Shen ZX, Wang ZY (1987) All-trans retinoic acid with or without low dose cytosine arabinoside in acute promyelocytic leukemia: report of 6 cases. Chinese Med J (English) 100 : 949–953
  3. Huang ME, Chen SR, Ye JC, Cai JR Lu JX, Huang LA, Pen M, Wu XZ, Zhang FJ, Wang ZY (1988) [Treatment of acute promyelocytic leukemia with all-trans retinoic acid]. Chinese Journal of Medicine (Traduction en PubMed: Zhonghua Yi Xue Za Zhi) 68 : 131–133.
  4. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhao L, Gu LJ, Wang ZY (1988). Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72 : 567–572. (ISI Citation Classic Award)
  5. Huang ME, Gobet M, Galibert F (1989). A modified M13 vector specially designed for easy ExoIII nested deletion sequencing. Meth Mol Cell Biol 1 : 161–164
  6. Chomienne C, Ballerini P, Balitrand N, Huang ME, Krawice I, Castaigne S, Fenaux P, Tiollais P, Dejean A, Degos L, de The H (1990). The retinoic acid receptor  gene is rearranged in retinoic acid-sensitive promyelocytic leukemias. Leukemia 4 : 802–807.
  7. Chomienne C, Ballerini P, Huang ME, Cornic M, Abita JP, Castaigne S, Degos L (1990). In vitro effects of retinoic acid. Nouv Rev Fr Hematol 32 : 32–34.
  8. Wang ZY, Sun GL, Lu JX, Gu LJ, Huang ME, Chen SR (1990) Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China. Nouv Rev Fr Hematol 32 : 34–36.

 

  1. Chen Z, Chen SJ, Tong JH, Zhu YJ, Huang ME, Wang WC, Wu Y, Sun GL, Wang ZY, Larsen CJ, Berger R (1991). The retinoic acid alpha receptor gene is frequently disrupted in its 5′ part in Chinese patients with acute promyelocytic leukemia. Leukemia 5 : 288–292.
  2. Wu XZ, Shao GY, Chen SR, Huang ME, Wang ZY (1991). Protein kinase C in the promyelocytic leukemia cell differentiation of granulocytes. Chinese Med J (English) 104 : 32–35.
  3. Sun GL, Huang ME et al. (1992). The study on post-remision therapies in patients with APL after complete remission induced by all-trans retinoic acid. Chinese Journal of Cancer Research (English) 4 : 58–61.
  4. Huang ME, Chuat JC, Thierry A, Dujon B, Galibert F (1994). Construction of a cosmid contig and of an EcoRI restriction map of yeast chromosome X. DNA Sequence 4 : 293–300.
  5. Huang ME, Chuat JC, Galibert F (1994). A possible yeast homolog of human active-gene-repairing helicase ERCC6. Biochem Biophys Res Commun 201 : 310–317.
  6. Huang ME, Manus V, Chuat JC, Galibert F (1994). Revised nucleotide sequence of the COR region of yeast S. cerevisiae chromosome X. Yeast 10 : 811–818.
  7. Huang ME, Chuat JC, Galibert F (1994). A voltage-gated chloride channel in the yeast S. cerevisiae. J Mol Biol 242 : 595–598.
  8. Bach ML, Roelants E, de Montigne J, Huang ME, Potier S, Souciet JL (1995). Recovery of gene function by gene duplication in S. cerevisiae. Yeast 11 : 169–177.
  9. Huang ME, Chuat JC, Galibert F (1995). Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and fourteen new open reading frames including a gene probably belongs to the family of ubiquitin-protein ligase. Yeast 11 : 775–781.
  10. Bazarbachi A, Huang ME, Gessain A, Peries G, de The H, Galibert F (1995). HTLV-I complete proviral sequence from uncultured peripheral blood mononuclear cells derived from a subacute post-transfusional tropical spastic paraparesis. Int J Cancer 63 : 494–499.
  11. Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux J-C, Katsoulou C, Kirchrath L, Kleine K, Kordes E, Kötterv P, Liebl S, Louis EJ, Manus V, Mewes HW, Miosga T, Obermaier B, Perea J, Pohl T, Portetelle D, Pujo A, Purnelle B, Ramezani Rad M, Rasmussen SW, Rose M, Rossau R, Schaaff-Gerstenschläger I, Smits PHM, Scarcez T, Soriano N, Tovan D, Tzermia M, Van Broekhoven A, Vandenbo M, Wedler H, Von Wettstein D, Wambutt R, Zagulski M, Zöllner A, Karpfinger-Hartl L (1996). Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J 15 : 2031–2049.
  12. Huang ME, Manus V, Chuat JC, Galibert F (1996). Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI. Yeast 12 : 869–875
  13. Huang ME, Souciet JL, Chuat JC, Galibert F (1996). Identification of ACT4, a novel essential actin-related gene in the yeast S. cerevisiae. Yeast 12 : 839–848.
  14. Huang ME, Cadieu E, Souciet JL, Galibert F (1997). Disruption of six novel yeast genes reveals three genes essential for vegetative growth and one required for growth at low temperature. Yeast 13 : 1181–1194.
  15. Huang ME, Le Douarin B, Henry C, Galibert F (1999). The S. cerevisiae protein YJR043c (Pol32) interacts with the catalytic subunit of DNA polymerase  and is required for the progression of G2/M. Mol Gen Genet 260 : 541–550.
  16. Huang ME, de Calignon A, Nicolas A, Galibert F (2000). POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase  defines a link between DNA replication and the mutagenic bypass repair pathway. Curr Genet 38 : 178–187.
  17. Huang ME, Rio AG, Galibert MD, Galibert F (2002). Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase , suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics 160 : 1409–1422.
  18. Huang ME, Rio AG, Nicolas A, Kolodner RD (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci USA 100 : 11529–11534.
  19. Huang ME, Kolodner RD (2005). A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage. Mol Cell 17 : 709–720.
  20. Ragu S, Faye G, Iraqui I, Heneman-Masurel A, Kolodner RD, Huang ME (2007). Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death. Proc Natl Acad Sci USA 104 : 9747–9752.
  21. Iraqui I, Faye G, Ragu S, Heneman-Masurel A, Kolodner RD, Huang ME (2008). Human peroxiredoxin PrxI is an ortholog of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae. Cancer Res 68 : 1055–1063.
  22. Fourquet S, Huang ME, D’Autreaux B, Toledano MB (2008). The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling. Antioxid Redox Signal 10 : 1565–1576 (Review).
  23. Enserink JM, Hombauer H, Huang ME, Kolodner RD (2009). Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae. J Cell Biol 185 : 423–437.
  24. Iraqui I, Kienda G, Soeur J, Faye G, Baldacci G, Kolodner RD, Huang ME (2009). Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae. PLoS Genet 5 : e1000524.
  25. Sœur J, Marrot L, Perez P, Iraqui I, Kienda G, Dardalhon M, Meunier JR, Averbeck D, Huang ME (2011). Selective cytotoxicity of Aniba rosaeodora essential oil towards epidermoid cancer cells through induction of apoptosis. Mutat Res 718 : 24–32.
  26. Billot K, Soeur J, Chereau F, Arrouss I, Merle-Béral H, Huang ME, Mazier D, Baud V, Rebollo A (2011). Deregulation of AIOLOS expression in chronic lymphocytic leukemia is associated to epigenetic modifications. Blood 117 : 1917–1927.
  27. Soler N, Delagoutte E, Miron S, Facca C, Baïlle D, d’Autreaux B, Craescu G, Frapart YM, Mansuy D, Baldacci G, Huang ME, Vernis L (2011). Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Mol Microbiol 82 : 54–67.
  28. Baudouin-Cornu P, Lagniel G, Kumar C, Huang ME, Labarre J (2012). Glutathione degradation is a key determinant of glutathione homeostasis J Biol Chem 287 : 4552–4561.
  29. Soler N, Craescu CT, Gallay J, Frapart YM, Mansuy D, Raynal B, Baldacci G, Pastore A, Huang ME, Vernis L (2012). A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S containing yeast protein Dre2. FEBS J 279 : 2108–2119.
  30. Dardalhon M*, Kumar C*, Iraqui I*, Vernis L, Kienda G, Banach-Latapy A, He T, Chanet R, Faye G, Outten CE, Huang ME (2012). Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes. Free Radic Biol Med 52 : 2254–2265 (*first co-author).
  31. Huang W*, He T*, Chai C, Yang Y, Zhou P, Qiao X, Zhang B, Liu Z, Zheng Y, Wang J, Shi C, Lei L, Gao K, Li H, Zhong S, Yao L, Huang ME, Lei M (2012). Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS One 7 : e37693 (*first co-author).
  32. He T, Banach-Latapy A, Vernis L, Dardalhon M, Chanet R, Huang ME (2013). Peroxiredoxin 1 knockdown potentiates -lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals. Carcinogenesis 34 : 760–769.
  33. Banach-Latapy A, He T, Dardalhon M, Vernis L, Chanet R, Huang ME (2013). Redox-sensitive YFP sensors for monitoring dynamic compartment-specific glutathione redox state. Free Radic Biol Med 65 : 436–445.
  34. Hatem E, Berthonaud V, Dardalhon M, Lagniel G, Peggy Baudouin-Cornu P, Huang ME, Labarre J, Chedin S (2014). Glutathione is essential to preserve nuclear function and cell survival under oxidative stress. Free Radic Biol Med 67 : 103–114.
  35. Ragu S, Dardalhon M, Sharma S, Iraqui I, Buhagiar-Labarchède G, Grondin V, Kienda G, Vernis L, Chanet R, Kolodner RD, Huang ME*, Faye G (2014). Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants. PLoS One 9 : e108123 (*corresponding author).
  36. Mayi T, Facca C, Anne S, Vernis L, Huang ME, Legraverend M, Faye G (2015). Yeast as a model system to screen purine derivatives against human CDK1 and CDK2 kinases. J Biotechnol 195 : 30–36.
  37. Chanet R, Kienda G, Heneman-Masurel A, Vernis L, Cassinat B, Guardiola P, Fenaux P, Chomienne C, Huang ME (2015). Yeast assay highlights the intrinsic genomic instability of human PML intron 6 over intron 3 and the role of replication fork proteins. PLoS One 10 : e0129222.
  38. He T, Hatem E, Vernis L, Lei M, Huang ME (2015). PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. J Exp Clin Cancer Res 34 : 153.
  39. Huang ME, Facca C, Fatmi Z, Baïlle D, Bénakli S, Vernis L (2016). DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo. Sci Rep 6 : 29361.
  40. Bui AH, Huang ME, Havard M, Laurent-Tchenio F, Dautry F, Tchenio T (2017). Transient exposure to androgens induces a remarkable self-sustained quiescent state in dispersed prostate cancer cells. Cell Cycle 16 : 879–893.
  41. Hatem E, El Banna N, Huang ME (2017). Multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance. Antioxid Redox Signal 27 : 1217–1234 (Review).
  42. Toledano MB, Huang ME (2017). The unfinished puzzle of glutathione physiological functions, an old molecule that still retains many enigmas. Antioxid Redox Signal 27 : 1127–1129 (Forum Editorial).
  43. Vernis L, El Banna N, Baïlle D, Hatem E, Heneman A, Huang ME (2017). Fe-S clusters emerging as targets of therapeutic drugs. Oxid Med Cell Longev 2017 : 3647657 (Review).
  44. Hatem E, Azzi S, El Banna N, He T, Heneman-Masurel A, Vernis L, Baïlle D, Masson V, Dingli F, Loew D, Azzarone B, Eid P, Baldacci G, Huang ME (2019). Auranofin/vitamin C: a novel drug combination targeting triple-negative breast cancer. J Natl Cancer Inst 111(6): 597-608. doi: 10.1093/jnci/djy149.
  45. Delort F, Segard BD, Hakibilen C, Bourgois-Rocha F, Cabet E, Vicart P, Huang ME, Clary G, Lilienbaum A, Agbulut O, Batonnet-Pichon S (2019). Alterations of redox dynamics and desmin post-translational modifications in skeletal muscle models of desminopathies. Exp Cell Res 383(2):111539. doi: 10.1016/j.yexcr.2019.111539.
  46. Lévy E, El Banna N, Baïlle D, Heneman-Masurel A, Truchet S, Rezaei H, Huang ME, Béringue V, Martin D, Vernis L (2019). Causative Links between Protein Aggregation and Oxidative Stress: A Review. Int J Mol Sci 20(16) : 3896. doi: 10.3390/ijms20163896.
  47. El Banna N, Hatem E, Heneman-Masurel A, Léger T, Baïlle D, Vernis L, Garcia C, Martineau S, Dupuy C, Vagner S, Camadro JM, Huang ME (2019). Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death. Redox Biol 26:101290. doi: 10.1016/j.redox.2019.101290.
  48. Qiu X, Guittet O, Mingoes C, El Banna N,Huang ME, Lepoivre M, Hildebrandt N (2019). Quantification of Cellular Deoxyribonucleoside Triphosphates by Rolling Circle Amplification and Förster Resonance Energy Transfer. Anal Chem 91(22):14561-14568. doi: 10.1021/acs.analchem.9b03624.
  49. Lévy E, Jaffrezic F, Laloë D, Rezaei H, Huang ME, Béringue V, Martin D, Vernis L (2020). PiQSARS: A pipeline for quantitative and statistical analyses of ratiometric fluorescent biosensors. MethodsX doi: 10.1016/j.mex.2020.101034.

Publication (Book Chapter)

Banach-Latapy A, Dardalhon M, Huang ME. Redox-sensitive Yellow Fluorescent Protein sensor for monitoring nuclear glutathione redox dynamics. In: The Nucleus. Second Edition. Ronald Hancock (Ed). Humana Press, 2015; pp159–169. 

Brevet

Use of essential oil of oregano or of rosewood for the treatment of cancerous keratoses.

(Utilisation d’huile essentielle d’origan ou de bois de rose, ou leurs constituants, dans le traitement thérapeutique des kératoses).

Patent number: 9040103

Inventeurs : Laurent Marrot, Jérémie Soeur, Meng-Er Huang

Déposant :  L’Oreal, Institut Curie, Centre National de la Recherche Scientifique

Numéro de publication : WO2011104490 A3, EP 2538933 A2, US 9040103 B2, US 20130059921 A1, WO 2011104490 A2

Date de dépôt : 28 févr. 2011

  1. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhao L, Gu LJ, Wang ZY (1988). Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72 : 567–572. (ISI Citation Classic Award)
  2. Chomienne C, Ballerini P, Balitrand N, Huang ME, Krawice I, Castaigne S, Fenaux P, Tiollais P, Dejean A, Degos L, de The H (1990). The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias. Leukemia 4 : 802–807.
  3. Chen Z, Chen SJ, Tong JH, Zhu YJ, Huang ME, Wang WC, Wu Y, Sun GL, Wang ZY, Larsen CJ, Berger R (1991). The retinoic acid alpha receptor gene is frequently disrupted in its 5′ part in Chinese patients with acute promyelocytic leukemia. Leukemia 5 : 288–292.
  4. Huang ME, Chuat JC, Galibert F (1994). A voltage-gated chloride channel in the yeast S. cerevisiae. J Mol Biol 242 : 595–598.
  5. Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux J-C, Katsoulou C, Kirchrath L, Kleine K, Kordes E, Kötterv P, Liebl S, Louis EJ, Manus V, Mewes HW, Miosga T, Obermaier B, Perea J, Pohl T, Portetelle D, Pujo A, Purnelle B, Ramezani Rad M, Rasmussen SW, Rose M, Rossau R, Schaaff-Gerstenschläger I, Smits PHM, Scarcez T, Soriano N, Tovan D, Tzermia M, Van Broekhoven A, Vandenbo M, Wedler H, Von Wettstein D, Wambutt R, Zagulski M, Zöllner A, Karpfinger-Hartl L (1996). Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J 15 : 2031–2049.
  6. Huang ME, Rio AG, Galibert MD, Galibert F (2002). Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase , suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics 160 : 1409–1422.
  7. Huang ME, Rio AG, Nicolas A, Kolodner RD (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci USA 100 : 11529–11534.
  8. Huang ME, Kolodner RD (2005). A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage. Mol Cell 17 : 709–720.
  9. Ragu S, Faye G, Iraqui I, Heneman-Masurel A, Kolodner RD, Huang ME (2007). Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death. Proc Natl Acad Sci USA 104 : 9747–9752.
  10. Iraqui I, Faye G, Ragu S, Heneman-Masurel A, Kolodner RD, Huang ME (2008). Human peroxiredoxin PrxI is an ortholog of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae. Cancer Res 68 : 1055–1063.
  11. Iraqui I, Kienda G, Soeur J, Faye G, Baldacci G, Kolodner RD, Huang ME (2009). Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae. PLoS Genet 5 : e1000524.
  12. Billot K, Soeur J, Chereau F, Arrouss I, Merle-Béral H, Huang ME, Mazier D, Baud V, Rebollo A (2011). Deregulation of AIOLOS expression in chronic lymphocytic leukemia is associated to epigenetic modifications. Blood 117 : 1917–1927.
  13. Baudouin-Cornu P, Lagniel G, Kumar C, Huang ME, Labarre J (2012). Glutathione degradation is a key determinant of glutathione homeostasis J Biol Chem 287 : 4552–4561.
  14. Dardalhon M*, Kumar C*, Iraqui I*, Vernis L, Kienda G, Banach-Latapy A, He T, Chanet R, Faye G, Outten CE, Huang ME (2012). Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes. Free Radic Biol Med 52 : 2254–2265 (*first coauthor).
  15. He T, Banach-Latapy A, Vernis L, Dardalhon M, Chanet R, Huang ME (2013). Peroxiredoxin 1 knockdown potentiates -lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals. Carcinogenesis 34 : 760–769.
  16. Banach-Latapy A, He T, Dardalhon M, Vernis L, Chanet R, Huang ME (2013). Redox-sensitive YFP sensors for monitoring dynamic compartment-specific glutathione redox state. Free Radic Biol Med 65 : 436–445.
  17. Ragu S, Dardalhon M, Sharma S, Iraqui I, Buhagiar-Labarchède G, Grondin V, Kienda G, Vernis L, Chanet R, Kolodner RD, Huang ME*, Faye G (2014). Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants. PLoS One 9 : e108123 (*corresponding author).
  18. Chanet R, Kienda G, Heneman-Masurel A, Vernis L, Cassinat B, Guardiola P, Fenaux P, Chomienne C, Huang ME (2015). Yeast assay highlights the intrinsic genomic instability of human PML intron 6 over intron 3 and the role of replication fork proteins. PLoS One 10 : e0129222.
  19. He T, Hatem E, Vernis L, Lei M, Huang ME (2015). PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug. J Exp Clin Cancer Res 34 : 153.
  20. Huang ME, Facca C, Fatmi Z, Baïlle D, Bénakli S, Vernis L (2016). DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo. Sci Rep 6 : 29361.
  21. Hatem E, El Banna N, Huang ME (2017). Multifaceted roles of glutathione and glutathione-based systems in carcinogenesis and anticancer drug resistance. Antioxid Redox Signal 27 : 1217–1234 (Review).
  22. Vernis L, El Banna N, Baïlle D, Hatem E, Heneman A, Huang ME (2017). Fe-S clusters emerging as targets of therapeutic drugs. Oxid Med Cell Longev 2017 : 3647657 (Review).
  23. Hatem E, Azzi S, El Banna N, He T, Heneman-Masurel A, Vernis L, Baïlle D, Masson V, Dingli F, Loew D, Azzarone B, Eid P, Baldacci G, Huang ME (2019). Auranofin/vitamin C: a novel drug combination targeting triple-negative breast cancer. J Natl Cancer Inst 111(6): 597-608. doi: 10.1093/jnci/djy149.
  24. El Banna N, Hatem E, Heneman-Masurel A, Léger T, Baïlle D, Vernis L, Garcia C, Martineau S, Dupuy C, Vagner S, Camadro JM, Huang ME (2019). Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death. Redox Biol 26:101290. doi: 10.1016/j.redox.2019.101290.

CNRS Research Director
(ORCID)

ICSN-CNRS Bât. 23b

1, avenue de la Terrasse

91190 Gif-sur-Yvette France

meng-er.huang@cnrs.fr

+33 1 69 82 37 76