Publications récentes


  • [DOI] Mai, P.-Y.; Poupon, E.; Ouazzani, J.; Obame, R. M.; Lopes, P.; Retailleau, P.; Gallard, J.-F.; Leblanc, K.; Moppert, X.; Costa, B.; Goff, G. L.; Beniddir, M.. Spirobistetrodecamycins A and B: Spontaneous Dimeric Spiro-fused Vinyl Cyclobutanes of Tetrodecamycin. Tetrahedron 2023, 149, 133712. doi:10.1016/j.tet.2023.133712
  • [DOI] Messé, E.; Labrunie, A.; Servajean, V.; Rubéru, C.; Jeanne-Julien, L.; Gallard, J.-F.; Steinmetz, V.; Roulland, E.; Norsikian, S.. Successiveß‐glycosylations of Tiacumicinone: Formal Total Synthesis of Tiacumicin B and Access to a D‐mannoside Analog. European Journal of Organic Chemistry 2023. doi:10.1002/ejoc.202301098
  • [DOI] Szwarc, S.; Jagora, A.; Derbré, S.; Leblanc, K.; Rharrabti, S.; Said-Hassane, C.; Kalamouni, C. E.; Gallard, J.-F.; Pogam, P. L.; Beniddir, M.. Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus Roseus. Organic Letters 2023, 26 (1), 274–279. doi:10.1021/acs.orglett.3c03972
  • [DOI] Beniddir, M.; Jagora, A.; Szwarc, S.; Hafidi, W.; Gallard, J.-F.; Retailleau, P.; Buevich, A.; Pogam, P. L.. Unifying the Configuration of Historical Alkaloids from Borreria Capitata Through an Extensive Spectroscopic Reinvestigation. Phytochemistry 2023, 212, 113741. doi:10.1016/j.phytochem.2023.113741
  • [DOI] Shi, C.; Kaffy, J.; Ha-Duong, T.; Gallard, J.-F.; Pruvost, A.; Mabondzo, A.; Ciccone, L.; Ongeri, S.; Tonali, N.. Proteolytically Stable Diaza-peptide Foldamers Mimic Helical Hot Spots of Protein–protein Interactions and Act as Natural Chaperones. Journal of Medicinal Chemistry 2023, 66 (17), 12005–12017. doi:10.1021/acs.jmedchem.3c00611
  • [DOI] N’Nang, E. O.; Cauchie, G.; Retailleau, P.; Agnandji, S.; Gallard, J.-F.; Mouray, E.; Grellier, P.; Champy, P.; Pogam, P. L.; Beniddir, M.. From the Spectroscopic Reassessment of Authentic Alkaloid Samples to the Molecular Networking-guided Discovery of Criophylline-related Analogues from Callichilia Inaequalis. Journal of Natural Products 2023, 86 (5), 1202–1210. doi:10.1021/acs.jnatprod.2c01084
  • [DOI] Retailleau, P.; Ilunga, E. N. W.; Fontaine, V.; Gallard, J.-F.; Pogam, P. L.. Clarifying the Configuration of Pandamine by an Extensive Spectroscopic Reinvestigation of the Authentic 1964 Sample. Metabolites 2023, 13 (4), 470. doi:10.3390/metabo13040470
  • [DOI] Jagora, A.; Szwarc, S.; Litaudon, M.; Dumontet, V.; Gallard, J.-F.; Beniddir, M.; Pogam, P.. Structure Elucidation of an Aspidofractinine-type Monoterpene Indole Alkaloid from Melodinus Reticulatus. Zeitschrift für Naturforschung C 2023. doi:10.1515/znc-2022-0234
  • [DOI] Trac, A.; Issaad, C.; Beniddir, M.; Bellanger, J.-M.; Gallard, J.-F.; Buevich, A.; Elyashberg, M.; Pogam, P.. Ominoxanthone—the First Xanthone Linearly Fused to a Γ-lactone from Cortinarius Ominosus Bidaud Basidiomata. CASE- and Dft-based Structure Elucidation. Molecules 2023, 28 (4), 1557. doi:10.3390/molecules28041557


  • [DOI] Vásquez-Ocmín, P.; Gallard, J.-F.; Baelen, A.-C.; Leblanc, K.; Cojean, S.; Mouray, E.; Grellier, P.; Guerra, C.; Beniddir, M.; Evanno, L.; Figadère, B.; Maciuk, A.. Biodereplication of Antiplasmodial Extracts: Application of the Amazonian Medicinal Plant Piper Coruscans Kunth. Molecules 2022, 27 (21), 7638. doi:10.3390/molecules27217638
  • [DOI] Nang, E. N.; Gallard, J.-F.; Champy, P.; Pogam, P.; Beniddir, M.. Density Functional Theory-nuclear Magnetic Resonance-validated Full Structure Elucidation of Theionbrunonine C, an Unstable N -oxide Theionbrunonine from Mostuea Brunonis. Magnetic Resonance in Chemistry 2022, 60 (12), 1178–1184. doi:10.1002/mrc.5271
  • [DOI] Fouotsa, H.; Mkounga, P.; Lannang, A.; Vanheuverzwijn, J.; Zhou, Z.; Leblanc, K.; Rharrabti, S.; Nkengfack, A.; Gallard, J.-F.; Fontaine, V.; Meyer, F.; Poupon, E.; Pogam, P.; Beniddir, M.. Pyrrovobasine, Hybrid Alkylated Pyrraline Monoterpene Indole Alkaloid Pseudodimer Discovered Using a Combination of Mass Spectral and Nmr-based Machine Learning Annotations. Organic & Biomolecular Chemistry 2022, 20 (1), 98–105. doi:10.1039/d1ob01791h


  • [DOI] Fouotsa, H.; Pogam, P.; Mkounga, P.; Lannang, A.; Bernadat, G.; Vanheuverzwijn, J.; Zhou, Z.; Leblanc, K.; Rharrabti, S.; Nkengfack, A.; Gallard, J.-F.; Fontaine, V.; Meyer, F.; Poupon, E.; Beniddir, M.. Voatriafricanines A and B, Trimeric Vobasine-aspidosperma-aspidosperma Alkaloids from Voacanga Africana. Journal of Natural Products 2021, 84 (10), 2755–2761. doi:10.1021/acs.jnatprod.1c00812
  • [DOI] Orango-Bourdette, J.; Beniddir, M.; Nang, E. N.; Gallard, J.-F.; Ondo, J.; Obiang, C.; Rharrabti, S.; Miel, C.; Denis, S.; Engonga, L.; Pogam, P.. Structure Elucidation of a New Lanostane Triterpene from Gabonese Ganoderma Orbiforme Fruiting Bodies. Magnetic Resonance in Chemistry 2021, 59 (11), 1165–1170. doi:10.1002/mrc.5214
  • [DOI] Jagora, A.; Gallard, J.-F.; Beniddir, M.; Pogam, P.. A Reappraisal of the Structure of Lyaline as the First Naturally Occurring Nacycline Monoterpene Indole Alkaloid. Journal of Natural Products 2021, 84 (9), 2617–2622. doi:10.1021/acs.jnatprod.1c00572
  • [DOI] Kouamé, T.; Bernadat, G.; Turpin, V.; Litaudon, M.; Okpekon, A.; Gallard, J.-F.; Leblanc, K.; Rharrabti, S.; Champy, P.; Poupon, E.; Beniddir, M.; Pogam, P.. Structure Reassignment of Melonine and Quantum-chemical Calculations-based Assessment of Biosynthetic Scenarios Leading to Its Revised and Original Structures. Organic Letters 2021, 23 (15), 5964–5968. doi:10.1021/acs.orglett.1c02055


  • [DOI] Tamon, A. N.; Okpekon, A.; Bony, N.; Bernadat, G.; Gallard, J.-F.; Kouamé, T.; Séon-Méniel, B.; Leblanc, K.; Rharrabti, S.; Mouray, E.; Grellier, P.; Ake, M.; Amin, N.; Champy, P.; Beniddir, M.; Pogam, P.. Streamlined Targeting of Amaryllidaceae Alkaloids from the Bulbs of Crinum Scillifolium Using Spectrometric and Taxonomically-informed Scoring Metabolite Annotations. Phytochemistry 2020, 179, 112485. doi:10.1016/j.phytochem.2020.112485
  • [DOI] Turpin, V.; Beniddir, M.; Genta-Jouve, G.; Skiredj, A.; Gallard, J.-F.; Leblanc, K.; Pogam, P.; Poupon, E.. In Silico Anticipation of Metabolic Pathways Extended to Organic Chemistry Reactions: A Case Study with Caffeine Alkaline Hydrolysis and the Origin of Camellimidazoles. Chemistry – A European Journal 2020, 26 (57), 12936–12940. doi:10.1002/chem.202002196
  • [DOI] Cauchie, G.; N'Nang, E.; Hooft, J.; Pogam, P.; Bernadat, G.; Gallard, J.-F.; Kumulungui, B.; Champy, P.; Poupon, E.; Beniddir, M.. Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-informed Molecular Networking. Organic Letters 2020, 22 (15), 6077–6081. doi:10.1021/acs.orglett.0c02153
  • [DOI] Kouamé, T.; Okpekon, A.; Bony, N.; N'Tamon, A.; Gallard, J.-F.; Rharrabti, S.; Leblanc, K.; Mouray, E.; Grellier, P.; Champy, P.; Beniddir, M.; Pogam, P.. Corynanthean-epicatechin Flavoalkaloids from Corynanthe Pachyceras. Molecules 2020, 25 (11), 2654. doi:10.3390/molecules25112654
  • [DOI] Nguyen, V.-K.; Genta-Jouve, G.; Duong, T.-H.; Beniddir, M.; Gallard, J.-F.; Ferron, S.; Boustie, J.; Mouray, E.; Grellier, P.; Chavasiri, W.; Pogam, P.. Eumitrins C-E: Structurally Diverse Xanthone Dimers from the Vietnamese Lichen Usnea Baileyi. Fitoterapia 2020, 141, 104449. doi:10.1016/j.fitote.2019.104449
  • [DOI] Alcover, C.; Bernadat, G.; Kabran, F.; Pogam, P.; Leblanc, K.; Ramos, A.; Gallard, J.-F.; Mouray, E.; Grellier, P.; Poupon, E.; Beniddir, M.. Molecular Networking Reveals Serpentinine-related Bisindole Alkaloids from Picralima Nitida, a Previously Well-investigated Species. Journal of Natural Products 2020, 83 (4), 1207–1216. doi:10.1021/acs.jnatprod.9b01247


  • [DOI] Goff, G.; Lopes, P.; Arcile, G.; Vlachou, P.; Elslande, E.; Retailleau, P.; Gallard, J.-F.; Weis, M.; Benayahu, Y.; Fokialakis, N.; Ouazzani, J.. Impact of the Cultivation Technique on the Production of Secondary Metabolites by Chrysosporium Lobatum TM -237-S5, Isolated from the Sponge Acanthella Cavernosa. Marine Drugs 2019, 17 (12), 678. doi:10.3390/md17120678
  • [DOI] Jarret, M.; Turpin, V.; Tap, A.; Gallard, J.-F.; Kouklovsky, C.; Poupon, E.; Vincent, G.; Evanno, L.. Bioinspired Oxidative Cyclization of the Geissoschizine Skeleton for Enantioselective Total Synthesis of Mavacuran Alkaloids. Angewandte Chemie International Edition 2019, 58 (29), 9861–9865. doi:10.1002/anie.201905227
  • [DOI] Chevallier, M.; Della-Negra, O.; Chaussonnerie, S.; Barbance, A.; Muselet, D.; Lagarde, F.; Darii, E.; Ugarte, E.; Lescop, E.; Fonknechten, N.; Weissenbach, J.; Woignier, T.; Gallard, J.; Vuilleumier, S.; Imfeld, G.; Paslier, D.; Saaidi, P.. Natural Chlordecone Degradation Revealed by Numerous Transformation Products Characterized in Key French West Indies Environmental Compartments. Environ Sci Technol 2019, 53 (11), 6133–6143. doi:10.1021/acs.est.8b06305


  • [DOI] Silva, S.; Oberhänsli, F.; Tribalat, M.-A.; Genta-Jouve, G.; Teyssié, J.-L.; Dechraoui-Bottein, M.-Y.; Gallard, J.-F.; Evanno, L.; Poupon, E.; Thomas, O.. Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges. Angewandte Chemie International Edition 2018, 58 (2), 520–525. doi:10.1002/anie.201809539
  • [DOI] Hoang, T.; Roullier, C.; Boumard, M.-C.; Pont, T.; Nazih, H.; Gallard, J.-F.; Pouchus, Y.; Beniddir, M.; Grovel, O.. Metabolomics-driven Discovery of Meroterpenoids from a Mussel-derived Penicillium Ubiquetum. Journal of Natural Products 2018, 81 (11), 2501–2511. doi:10.1021/acs.jnatprod.8b00569
  • [DOI] Thuc-Huy, D.; Beniddir, M.; Van-Kieu, N.; Aree, T.; Gallard, J.-F.; Dinh-Hung, M.; Huu-Hung, N.; Xuan-Hao, B.; Boustie, J.; Kim-Phi-Phung, N.; Chavasiri, W.; Pogam, P.. Sulfonic Acid-containing Flavonoids from the Roots of Phyllanthus Acidus. Journal of Natural Products 2018, 81 (9), 2026–2031. doi:10.1021/acs.jnatprod.8b00322
  • [DOI] Vlachou, P.; Goff, G.; Alonso, C.; Alvarez, P.; Gallard, J.-F.; Fokialakis, N.; Ouazzani, J.. Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-up Technology for Open Marine Ecosystems. Marine Drugs 2018, 16 (5). doi:10.3390/md16050152

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Jean-François Gallard (01 69 82 31 25) Responsable
François Giraud (01 69 82 37 64)