CV A. Claraz

2023 Habilitation, Paris-Saclay University, France
2017-now CNRS research associate, UPR 2301, Institut de Chimie des Substances Naturelles, France.
2016-2017 Postdoctoral researcher, Ecole supérieure de physique et de chimie industrielles de Paris, team of Pr Janine COSSY, France.
2015-2016 Temporary assistant lecturer, Ecole de ChimieParisTech, team of Dr Sylvain DARSES, France.
2013-2015 Postdoctoral researcher, University of Jyväskylä, team of Pr. Petri PIHKO, Finland.
2009-2012 Ph.D. degree, INSA Rouen, team of Dr Vincent LEVACHER, France.
2009 Ms.C degree in synthetic chemistry. University Claude Bernard Lyon 1, France (research internship of 5 months in the group of Pr. Marc LEMAIRE).

Electrosynthesis – Photocatalysis – Organocatalysis – Asymmetric catalysis – Chiral catalyst design


« Divergent cyclodimerizations of styrylnaphthols under aerobic visible-light irradiation and Brønsted acid catalysis. » Lyu, J.; Claraz, A.;* Retailleau, P.; Masson, G.* Org. Biomol. Chem. 2022, 20, 9593.
« Recent Advances in C(sp3)–C(sp3) and C(sp3)–C(sp2) Bond Formation through Cathodic Reactions: Reductive and Convergent Paired Electrolyses. » Claraz, A.;* Masson, G.* ACS Org. Inorg. Au 2022, 2, 126.
« s-Tetrazine: robust and green photoorganocatalyst for aerobic oxidation of N,N-disubstituted hydroxylamines to nitrones. » Lyu, J.; Le, T.; Claraz, A.; Allain, C.; Audebert, P.; Masson, G.* Synlett 2022, 33, 177.
« Electroreductive cross-coupling of trifluoromethyl alkenes and redox active esters for the synthesis of gem-difluoroalkenes. » Claraz, A.;* Allain, C.; Masson, G.* Chem. Eur. J. 2022, 28, e202103337.
« Electrochemical tandem trifluoromethylation of allylamines/formal (3+2)-cycloaddition for the rapid access to CF3-containing imidazolines and oxazolidines » Claraz, A.;* Djian, A.; Masson, G.* Org. Chem. Front. 2021, 8, 288.
« Preparation of chiral photosensitive organocatalysts and their application for the enantioselective synthesis of 1,2-diamines » Lyu, J.-Y.; Claraz, A.; Vitale, M. R.; Allain, C.; Masson, G.* J. Org. Chem. 2020, 20, 12843.
« Catalytic enantioselective synthesis of (+)-Lycoperdic acid » Kortet, S.; Claraz, A.; Pihko, P. M.* Org. Lett. 2020, 22, 3010.
« Electrochemical intramolecular oxytrifluoromethylation of N-tethered alkenyl alcohols: synthesis of functionalized morpholines » Claraz, A.;* Courant, T.; Masson, G.* Org. Lett. 2020, 22, 1580.
« Asymmetric iodine catalysis-mediated enantioselective oxidative transformations » Claraz, A.;* Masson, G.* Org. Biomol. Chem. 2018, 16, 5386.
« N-formylsaccharin » Claraz, A.; Daniel-Bertrand M.; Cossy, J. Encyclopedia of reagents for organic synthesis 2018.
10. « Selective generation of (1H‐1,2,4‐triazol‐1‐yl)methyl carbanion and condensation with carbonyl compounds » Lassalas, P.; Claraz, A., Tran, G.; Vors, J.-P.; Tsuchiya, T.; Coqueron, P.-Y.; Cossy, J.* Eur. J. Org. Chem. 2017, 6991.
9. « Organoboron initiated Rh-catalyzed asymmetric cascade reactions: a subtle switch in regioselectivity leading to chiral 3‑benzazepine derivatives » Claraz, A.; Serpier, F.; Darses, S.* ACS Catal. 2017, 7, 3410.
8. « A catalyst designed for the enantioselective construction of methyl‐ and alkyl‐substituted tertiary stereocenters » Claraz, A.; Sahoo, G.; Berta, D.; Madarasz, A.; Papai, I.; Pihko, P. M.* Angew. Chem. Int. Ed. 2016, 55, 669.
7. « Asymmetric organocatalytic protonation of silyl enolate catalyzed by simple and original betaines derived from Cinchona alkaloids » Claraz, A.; Landelle, G.; Oudeyer, S.;* Levacher, V.* Eur. J. Org. Chem. 2013, 7693.
6. « Enantioselective desymmetrization of prochiral ketones via an organocatalytic deprotonation process. » Claraz, A.; Oudeyer, S.;* Levacher, V.* Tetrahedron: Asymmetry 2013, 24, 764.
5. « Chiral quaternary ammonium aryloxide/N,O-bis(trimethylsilylamide) combination as efficient organocatalytic system for the direct vinylogous aldol reaction of (5H)-furan-2-one derivatives » Claraz, A.; Oudeyer, S.;* Levacher, V.* Adv. Synth. Catal. 2013355, 841.
4. « N,O-bis(trimethylsilylamide) » Claraz, A. Synlett 2012, 24, 657.
3. « Deracemization of alpha-substituted carbonyl compounds via catalytic enantioselective protonation of their corresponding enolates » Claraz, A.; Oudeyer, S.;* Levacher, V.* Current Organic Chemistry 2012, 16, 2192.
2. « Water-promoted one-pot vinylogous Mannich-type reaction of trimethylsilyloxyfuran » Landelle, S.; Claraz, A.; Oudeyer, S.;* Levacher, V.* Tetrahedron Lett. 2012, 53, 2414. 
1. « Catalytic enantioselective protonation of enol trifluoroacetates by means of hydrogenocarbonates and Cinchona alkaloids » Claraz, A.; Leroy, J.; Oudeyer, S.;* Levacher, V.* J. Org. Chem. 2011, 76, 6457.


Book chapters:

3. « Asymmetric visible light photoredox catalysis » Lyu, J.-Y.; Claraz, A.; Masson, G. in Catalytic asymmetric synthesis fourth edition, Chapter 8, John Wiley VCH 2021, Ed: Akiyama, A.; Ojima, I. submitted.
2. « Bicyclic 5-6 Systems with one bridgehead (ring junction) nitrogen atom: Four extra heteroatoms 2:2 » Claraz, A. in Comprehensive Heterocyclic Chemistry IV, Elsevier 2021.
1. « Iminium Catalysis » Claraz, A.; Siitonen, J. H.; Pihko, P. M. in Lewis Base Catalysis in Organic Synthesis, Chapter 16, Wiley-VCH 2016, Ed: Vedejs, E.; Denmark, S. E.

Invited Lectures:

5. ICMMO, Paris-Saclay University,  Orsay, France, 21st March 2023. « Electrochemistry: a valuable approach for organic synthesis. » 
4. Scientific days of Labex Charm3at, Gif-sur-Yvette, France, 1st December 2022. « An electrochemical approach towards the synthesis of fluorine-containing compounds »
3. Journée des chargés de recherche de l’INC, promotion 2017, Paris, France, 18th October 2022. « Une approche électrochimique pour la synthèse de molécules fluorées. »
2. LSO, Ecole Polytechnique Palaiseau,  France, 10th October 2022. « Electrochemistry: a valuable approach for organic synthesis. » 
1. Journée du département de chimie de l’université Paris-Saclay, Saint Aubin, France, 10th October 2019. « Difonctionnalisation d’allylamines par électrochimie: synthèse d’azacycles trifluorométhylés ».


Other Communications:

3. Organic chemistry days of the French chemical society (JCO), Palaiseau, France, 29th October 2019. « Electrochemical trifluoromethylative difunctionalization of allylamines: access to CF3-containing azacycles.
2. Normand chemistry graduate school day, Caen, France, 31st December 2011. « Catalytic enantioselective protonation of enol trifluoroacetate. »
1. 3ème séminaire « UMR 6014/Jansssen Cilag: un partenariat durable », Rouen, France, 6th December 2010. « Protonation énatiosélective de trifluoroacétates d’énols »
2022 Outstanding Reviewer for Organic and Biomolecular Chemistry.
2022-2026 Young Researcher Grant from the French National Research Agency (ANR JCJC C3bond).
2022 Labex Charm3at. Collaboration with Dr Laurent ElKaïm (LSO, Polytechnique).
2022-2023 2nd level Master Course at Université Savoie Mont-Blanc: Asymmetric Organocatalysis.

ICSN : Member of the “bibliographic seminars committee” 

CNRS Research Associate


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