CV A. Chevalier

Habilitation à Diriger des Recherches, Université Paris-Saclay
2018-now CNRS researcher CRCN, Institut de Chimie des Substances Naturelles, UPR-CNRS 2301, Gif-Sur-Yvette, France.
2017-2018 Post-doctoral Fellow at CEA Saclay (Saclay, France, Dr Frédéric Taran).
2016-2017 Post-doctoral Fellow at Department of Bioorganic Chemistry (Rouen, France, Dr Xavier Franck).
2014-2016 Post-doctoral Fellow at Arizona State University (US, Tempe AZ, with Pr Sidney M. Hecht).
2011-2014 PhD at Department of Bioorganic Chemistry (UMR-CNRS 6014, Rouen, France) under the supervizion of Prof. Pierre-Yves Renard and Prof. Anthony Romieu

Synthesis and functionalization of organic fluorophores

Smart fluorogenic probes as sensors for enzymatic activities

Self immolative linkers

Drug delivery

  1. Michel, L. ; Auvray, M. ; Askenatzis, L. ; Badet-Denisot, M.-A. ; Bignon, J. ; Durand, P. ; Mahuteau-Betzer F. and Chevalier, A. Visualization of an Endogenous Mitochondrial Azoreductase Activity under Normoxic Conditions Using a Naphthalimide Azo-Based Fluorogenic Probe, Anal. Chem. 2024, 96 (4), 1774–1780, 10.1021/acs.analchem.3c05030
  2. Tacke, E.; Hoang, M.-D.; Tatoueix, K.; Keromnes, B.; Van Eslande, E.; Durand, P.; Pieters, G.; Chevalier, A., Unprecedented perspectives on the application of CinNapht fluorophores provided by a ′′late-stage′′ functionalization strategy. Chem. Sci. 2023, 14 (22), 6000-6010, 10.1039/d3sc01365k.
  3. Riberaud, M.; Porte, K.; Chevalier, A.; Madegard, L.; Rachet, A.; Delaunay-Moisan, A.; Vinchon, F.; Thuery, P.; Chiappetta, G.; Champagne, P. A.; Pieters, G.; Audisio, D.; Taran, F., Fast and Bioorthogonal Release of Isocyanates in Living Cells from Iminosydnones and Cycloalkynes. J. Am. Chem. Soc. 2023, 145 (4), 2219-2229, 10.1021/jacs.2c09865.
  4. Hoang, M.-D.; Savina, F.; Durand, P.; Méallet-Renault, P. R.; Clavier, G.; Chevalier, A., Tunable Naphthalimide/Cinnoline-Fused (CinNapht) Hybrid Dyes for Fluorescence Imaging in Living Cells. ChemPhotoChem 2022, 6, e202200285, 10.1002/cptc.202200138
  5. Chevalier, A.; Zhang, Y.; Khdour, O. M.; Kaye, J. B.; Hecht, S. M., Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting. J. Am. Chem. Soc. 2016, 138 (37), 12009-12012, 10.1021/jacs.6b06229.

Complete list of publications

Dr. Gilles CLAVIER (ENS Paris/Saclay, UMR 8531, Orsay)

Pr. Rachel MEALLET-RENAULT (ISMO, UMR 8214, Orsay)

Dr. Florence MAHUTEAU-BETZER (I. Curie, Orsay)

Dr. Gregory PIETERS (CEA Saclay)

Dr. Anthony ROMIEU (ICMUB, UMR 6302, Dijon)

Dr. Frédéric TARAN (CEA Saclay)

ANR – PRC – SydFluo (ANR): 2024-2028

CHARM3AT Labex (ANR-11-rDEX-0003-02-RD280): 2022-2024

ANR – JCJC – MitoRedAct (ANR-21-CE18-0005-01): 2022-2025

Fondation ARC (ARCPJA12020060002151): 2021-2023

CHARM3AT Labex (ANR-11-rDEX-0003-02-RD207): 2020-2021


  • Member of conferences organization committee of ICSN
  • Member of the redaction committee for Twitter account of ICSN.
  • Member of Student Seminar committee of ICSN
  • Webmaster of Chemical Biology department for ICSN website

CNRS Research Associate, HDR 


1, avenue de la Terrasse

91190 Gif-sur-Yvette France

+33 1 69 82 30 59

ORCID, @AChevalier18