CV A. Chevalier

Education and work experience

2018-now	CNRS researcher CRCN, Institut de Chimie des Substances Naturelles, UPR-CNRS 2301, Gif-Sur-Yvette, France.
2017-2018	Post-doctoral Fellow at CEA Saclay (Saclay, France, Dr Frédéric Taran).
2016-2017	Post-doctoral Fellow at Department of Bioorganic Chemistry (Rouen, France, Dr Xavier Franck).
2014-2016	Post-doctoral Fellow at Arizona State University (US, Tempe AZ, with Pr Sidney M. Hecht).
2011-2014	PhD at Department of Bioorganic Chemistry (UMR-CNRS 6014, Rouen, France) under the supervizion of Prof. Pierre-Yves Renard and Prof. Anthony Romieu

Research Interests

Synthesis and functionalization of organic fluorophores

Smart fluorogenic probes as sensors for enzymatic activities

Self immolative linkers

Drug delivering

Scientific Communications

32 publications – 4 patents – H-Index : 13

7 oral communications and conferences, 3 poster communications

Complete list of publications

Chevalier, A., Naphthalimide/heterocycles fused hybrid dyes, how and why ? An overview of the latest developments in the quest for dyes with innovative optical properties. Org. Biomol. Chem. 2023, DOI: 10.1039/d3ob01035j Accepted.
Tacke, E.; Hoang, M.-D.; Tatoueix, K.; Keromnes, B.; Van Eslande, E.; Durand, P.; Pieters, G.; Chevalier, A., Unprecedented perspectives on the application of CinNapht fluorophores provided by a ′′late-stage′′ functionalization strategy. Chem. Sci. 2023, 14 (22), 6000-6010, 10.1039/d3sc01365k.
Riberaud, M.; Porte, K.; Chevalier, A.; Madegard, L.; Rachet, A.; Delaunay-Moisan, A.; Vinchon, F.; Thuery, P.; Chiappetta, G.; Champagne, P. A.; Pieters, G.; Audisio, D.; Taran, F., Fast and Bioorthogonal Release of Isocyanates in Living Cells from Iminosydnones and Cycloalkynes. J. Am. Chem. Soc. 2023, 145 (4), 2219-2229, 10.1021/jacs.2c09865.
Hoang, M.-D.; Savina, F.; Durand, P.; Meallet-Renault, P. R.; Clavier, G.; Chevalier, A., Tunable Naphthalimide/Cinnoline-Fused (CinNapht) Hybrid Dyes for Fluorescence Imaging in Living Cells. ChemPhotoChem 2022, 6 (11), e202200138, 10.1002/cptc.202200138.
de Saint Germain, A.; Clavé, G.; Schouveiler, P.; Pillot, J.-P.; Singh, A.-V.; Chevalier, A.; Daignan Fornier, S.; Guillory, A.; Bonhomme, S.; Rameau, C.; Boyer, F.-D., Expansion of the Strigolactone Profluorescent Probes Repertory: The Right Probe for the Right Application. Front. Plant. Sci. 2022, 13, 887347, 10.3389/fpls.2022.887347.
Boujut, M.; Chevalier, A.; Schapman, D.; Benard, M.; Galas, L.; Gallavardin, T.; Franck, X., Indazole versus indole-based cationic merocyanines with red shifted in-cellulo emission for selective mitochondria imaging. Dyes Pigm. 2022, 198, 109988, 10.1016/j.dyepig.2021.109988.
Renault, K.; Chevalier, A.; Bignon, J.; Jacquemin, D.; Richard, J.-A.; Romieu, A., Coumarin-Pyronin Hybrid Dyes: Synthesis, Fluorescence Properties and Theoretical Calculations. ChemPhotoChem 2021, 5 (9), 822-838, 10.1002/cptc.202100069.
Hoang, M.-D.; Bodin, J.-B.; Savina, F.; Steinmetz, V.; Bignon, J.; Durand, P.; Clavier, G.; Meallet-Renault, R.; Chevalier, A., « CinNapht » dyes: a new cinnoline/naphthalimide fused hybrid fluorophore. Synthesis, photo-physical study and use for bio-imaging. RSC Adv. 2021, 11 (48), 30088-30092, 10.1039/d1ra05110e.
Dejouy, G.; Renault, K.; Bonnin, Q.; Chevalier, A.; Michaudet, C.; Picquet, M.; Valverde, I. E.; Romieu, A., Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1H)-one-based Heterocycles. Org. Lett. 2020, 22 (16), 6494-6499, 10.1021/acs.orglett.0c02287.
Del Vecchio, A.; Talbot, A.; Caille, F.; Chevalier, A.; Sallustrau, A.; Loreau, O.; Destro, G.; Taran, F.; Audisio, D., Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation. Chem. Commun. 2020, 56 (78), 11677-11680, 10.1039/d0cc05031h.
Del Vecchio, A.; Caille, F.; Chevalier, A.; Loreau, O.; Horkka, K.; Halldin, C.; Schou, M.; Camus, N.; Kessler, P.; Kuhnast, B.; Taran, F.; Audisio, D., Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO2. Angew. Chem., Int. Ed. 2018, 57 (31), 9744-9748, 10.1002/anie.201804838.
Chevalier, A.; Ouahrouch, A.; Arnaud, A.; Gallavardin, T.; Franck, X., An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles. RSC Adv. 2018, 8 (24), 13121-13128, 10.1039/c8ra01546e.
Zhang, Y.; Chevalier, A.; Khdour, O. M.; Soto, L. M.; Hecht, S. M., Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A. Planta Med. 2017, 83 (18), 1377-1383, 10.1055/s-0043-112343.
Vivoli, M.; Renou, J.; Chevalier, A.; Norville, I. H.; Diaz, S.; Juli, C.; Atkins, H.; Holzgrabe, U.; Renard, P.-Y.; Sarkar-Tyson, M.; Harmer, N. J., A miniaturized peptidyl-prolyl isomerase enzyme assay. Anal. Biochem. 2017, 536, 59-68, 10.1016/j.ab.2017.08.004.
Makrerougras, M.; Coffinier, R.; Oger, S.; Chevalier, A.; Sabot, C.; Franck, X., Total Synthesis and Structural Revision of Chaetoviridins A. Org. Lett. 2017, 19 (15), 4146-4149, 10.1021/acs.orglett.7b02053.
Chevalier, A.; Renard, P.-Y.; Romieu, A., Azo-Based Fluorogenic Probes for Biosensing and Bioimaging: Recent Advances and Upcoming Challenges. Chem. – Asian J. 2017, 12 (16), 2008-2028, 10.1002/asia.201700682.
Chevalier, A.; Khdour, O. M.; Schmierer, M.; Bandyopadhyay, I.; Hecht, S. M., Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants. Bioorg. Med. Chem. 2017, 25 (5), 1703-1716, 10.1016/j.bmc.2017.01.030.
Chevalier, A.; Zhang, Y.; Khdour, O. M.; Kaye, J. B.; Hecht, S. M., Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting. J. Am. Chem. Soc. 2016, 138 (37), 12009-12012, 10.1021/jacs.6b06229.
Chevalier, A.; Zhang, Y.; Khdour, O. M.; Hecht, S. M., Selective Functionalization of Antimycin A Through an N-Transacylation Reaction. Org. Lett. 2016, 18 (10), 2395-2398, 10.1021/acs.orglett.6b00882.
Chevalier, A.; Alam, M. P.; Khdour, O. M.; Schmierer, M.; Arce, P. M.; Cripe, C. D.; Hecht, S. M., Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability. Bioorg. Med. Chem. 2016, 24 (21), 5206-5220, 10.1016/j.bmc.2016.08.039.
Roubinet, B.; Chevalier, A.; Renard, P.-Y.; Romieu, A., A Synthetic Route to 3-(Heteroaryl)-7-hydroxycoumarins Designed for Biosensing Applications. Eur. J. Org. Chem. 2015, 2015 (1), 166-182, 10.1002/ejoc.201403215.
Chevalier, A.; Renault, K.; Boschetti, F.; Renard, P.-Y.; Romieu, A., Rapid Synthesis of Unsymmetrical Sulforhodamines Through Nucleophilic Amination of a Monobrominated Sulfoxanthene Dye. Eur. J. Org. Chem. 2015, 2015 (1), 152-165, 10.1002/ejoc.201403165.
Chevalier, A.; Piao, W.; Hanaoka, K.; Nagano, T.; Renard, P.-Y.; Romieu, A., Azobenzene-caged sulforhodamine dyes: a novel class of ′turn-on′ reactive probes for hypoxic tumor cell imaging. Methods Appl. Fluoresc. 2015, 3 (4), 044004/1, 10.1088/2050-6120/3/4/044004.
Jouanno, L.-A.; Chevalier, A.; Sekkat, N.; Perzo, N.; Castel, H.; Romieu, A.; Lange, N.; Sabot, C.; Renard, P.-Y., Kondrat’eva Ligation: Diels-Alder-Based Irreversible Reaction for Bioconjugation. J. Org. Chem. 2014, 79 (21), 10353-10366, 10.1021/jo501972m.
Chevalier, A.; Renard, P.-Y.; Romieu, A., Straightforward Access to Water-Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-Red Fluorescent Dyes with Large Stokes’ Shifts. Chem. Eur. J. 2014, 20 (27), 8330-8337, 10.1002/chem.201402306.
Chevalier, A.; Renard, P.-Y.; Romieu, A., Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers. Org. Lett. 2014, 16 (15), 3946-3949, 10.1021/ol501753b.
Chevalier, A.; Renard, P.-Y.; Romieu, A., Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-1 (BHQ-1) scaffold. Tetrahedron Lett. 2014, 55 (50), 6759-6763, 10.1016/j.tetlet.2014.10.053.
Chevalier, A.; Renard, P.-Y.; Romieu, A., Straightforward synthesis of bioconjugatable azo dyes. Part 2: Black Hole Quencher-2 (BHQ-2) and BlackBerry Quencher 650 (BBQ-650) scaffolds. Tetrahedron Lett. 2014, 55 (50), 6764-6768, 10.1016/j.tetlet.2014.10.054.
Chevalier, A.; Mercier, C.; Saurel, L.; Orenga, S.; Renard, P.-Y.; Romieu, A., The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures. Chem. Commun. 2013, 49 (78), 8815-8817, 10.1039/c3cc44798g.
Chevalier, A.; Massif, C.; Renard, P.-Y.; Romieu, A., Bioconjugatable Azo-Based Dark-Quencher Dyes: Synthesis and Application to Protease-Activatable Far-Red Fluorescent Probes. Chem. Eur. J. 2013, 19 (5), 1686-1699, 10.1002/chem.201203427.
Chevalier, A.; Hardouin, J.; Renard, P.-Y.; Romieu, A., Universal Dark Quencher Based on « Clicked » Spectrally Distinct Azo Dyes. Org. Lett. 2013, 15 (23), 6082-6085, 10.1021/ol402972y.
Chevalier, A.; Dubois, M.; Le Joncour, V.; Dautrey, S.; Lecointre, C.; Romieu, A.; Renard, P.-Y.; Castel, H.; Sabot, C., Synthesis, Biological Evaluation, and in Vivo Imaging of the first Camptothecin-Fluorescein Conjugate. Bioconjugate Chem. 2013, 24 (7), 1119-1133, 10.1021/bc3005304.