2021

  • CACHEUX F, LE GOFF G, OUAZZANI J, BIGNON J, RETAILLEAU P, MARINETTI A, VOITURIEZ A and BETZER JF. The Piancatelli rearrangement of non-symmetrical furan-2,5-dicarbinols for the synthesis of highly functionalized cyclopentenones. Org Chem Front, 8: 2449, 2021, doi: 10.1039/d1qo00268f
  • PAYSANT H, HEDIR S, JUSTAUD F, WEISWALD LB, EL DINE AN, SOULIEMAN A, HACHEM A, ELIE N, BROTIN E, DENOYELLE C, BIGNON J, ROUSSI F, JOUANNE M, TASSEAU O, ROISNEL T, VOISIN-CHIRET AS, GREE R, LEVOIN N, POULAIN L. Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues. Org Biomol Chem, 2021, doi: 10.1039/d1ob01521d
  • RENAULT K, CHEVALIER A, BIGNON J, JACQUEMIN D, RICHARD JA, ROMIEU A. Coumarin-Pyronin Hybrid Dyes: Synthesis, Fluorescence Properties and Theoretical Calculations. ChemPhotoChem, 5 : 822, 2021, doi.org/10.1002/cptc.202100069
  • HOANG MD, BODIN JB, SAVINA F, STEINMETZ V, BIGNON J, DURAND P, CLAVIER G, MEALLET-RENAULT R, CHEVALIER A. “CinNapht” dyes: a new cinnoline/naphthalimide fused hybrid fluorophore. Synthesis, photophysical study and use for bio-imaging. RSC Advances, 11: 30088, 2021, doi: 10.1039/d1ra05110e
  • EL ABBOUCHI A, EL BRAHMI N, HIEBEL M-A, BIGNON J, GUILLAUMET G, SUZENET F, EL KAZZOULI S. Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents. Bioorg Chem, 115 : 105293, 2021, doi.org/10.1016/j.bioorg.2021.105293
  • MIGNANI S, BIGNON J, SHI X and MAJORAL JP. First-in-Class Phosphorus Dendritic Framework, a Wide SurfaceFunctional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn. Molecules, 26 : 3708, 2021, doi: 10.3390/molecules26123708
  • PECNARD S, HAMZE A, BIGNON J, PROST B, DEROUSSENT A, GALLEGO–YERGA L, PELAEZ R, PAIK JY, DIEDERICH M, ALAMI M, PROVOT O. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues. Eur J Med Chem, 223 : 113656, 2021, doi: 10.1016/j.ejmech.2021.113656
  • LEVAIQUE H, PAMLARD O, APEL C, BIGNON J, ARRIOLA M, KUHNER R, AWANG K, LOISEAU PM, LITAUDON M, POMEL S. Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities. Molecules, 26 : 1551, 2021, doi: 10.3390/molecules26061551
  • DARESSY F, MALARD F, SEGUY L, GUERINEAU V, APEL C, DUMONTET V, ROBERT A, GROO AC, LITAUDON M, BIGNON J, DESRAT S, MALZERT-FREON A, WIELS J, LESCOP E, ROUSSI F. Drimane derivatives as the first examples of covalent BH3-mimetics that target MCL-1. ChemMedChem, 16 : 1788, 2021, doi: 10.1002/cmdc.202100011
  • QIU J, CHEN L, ZHAN M, LAURENT R, BIGNON J, MIGNANI S, SHI X, CAMINADE AM, MAJORAL JP. Facile Synthesis of Amphiphilic Fluorescent Phosphorus Dendron-Based Micelles as Antiproliferative Agents: First Investigations. Bioconjug Chem, 2021, doi: 10.1021/acs.bioconjchem.0c00716
  • JUILLET C, ERMOLENKO L, BOYARSKAYA D, BARATTE B, JOSSELIN B, NEDEV H, BACH S, IORGA B, BIGNON J, RUCHAUD S, AL-MOURABIT A. From Synthetic Simplified Marine Metabolite Analogues to NewSelective Allosteric Inhibitor of Aurora B Kinase.  J MedChem, 64 :1197, 2021, doi: 10.1021/acs.jmedchem.0c02064
  • PECNARD S, PROVOT O, LEVAIQUE H, BIGNON J, ASKENATZIS L, SALLER F, BORGEL D, MICHALLET S, LAISNE MC, LAFANECHERE L, ALAMI M, HAMZE A. Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation. Eur J Med Chem, 2021, 209 : 112873, doi: 10.1016/j.ejmech.2020.112873

2020

  • EL-KHOURY F, BIGNON J and MARTIN JR. Jouvence, a new human snoRNA involved in the control of cell proliferation. BMC Genomics, 2020, 21 :817, doi.org/10.1186/s12864-020-07197-3
  • SAID HASSANE C, FOUILLAUD M, LE GOFF G, SKLIROU AD, BOYER JB, TROUGAKOS JP, JERABEK M, BIGNON J, de VOOGD NJ, OUAZZANI J, GAUVIN-BIALECKI A, DUFOSSE L. Microorganisms associated with the marine sponge Scopalina hapalia: a reservoir of bioactive molecules to slow down the aging process. Microorganisms, 2020, 8: 1262, DOI 10.3390/microorganisms8091262
  • EL ABBOUCHI A, EL BRAHMI N, HIEBEL MA, BIGNON J, GUILLAUMET G, SUZENET F, EL KAZZOULIA S. Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents. Bioorg Med Chem Lett., 2020, 30 : 127426 DOI.org/10.1016/j.bmcl.2020.127426
  • ZHANG K, EL BOUAKHER A, LEVAIQUE H, BIGNON J, RETAILLEAU P, ALAMI M, HAMZE H. Imidazodipyridines via DMAP Catalyzed Domino N−H Carbonylation and 6π‐Electrocyclization: Synthetic Scope and Application. Adv Synth Catal, 2020, 362 : 3243 DOI10.1002/adsc.202000553
  • CAMPOS PE, HERBETTE G, CHENDO C, CLERC P, TINTILLIER F, de VOOGD NJ, PAPANAGNOU ED, TROUGAKOS IP, JERABEK M, BIGNON J, LE GOFF G , OUAZZANI J and GAUVIN-BIALECKI A. Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp. Mar. Drugs, 2020, 18 : 350 DOI 10.3390/md18070350
  • PROVOT O, KHELIFI I, PECNARD S, BERNADAT G, BIGNON J, LEVAIQUE H, DUBOIS J, ALAMI M. Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuinesSynthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines.  ChemMedChem., 2020, 15 : 1571 DOI 10.1002/cmdc.202000197
  • IBRAHIM N, BONNET P, BRION JD, PEYRAT JF, BIGNON J, LEVAIQUE H, JOSSELIN B, ROBERT T, COLAS P, BACH S, MESSAOUDI S, ALAMI M, HAMZE A, Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency. Eur J Med Chem., 2020, 199:112355 DOI.org/10.1016/j.ejmech.2020.112355
  • MAJORAL JP, CHEN L, FAN Y, QIU J, LAURENT R, LI J, BIGNON J, MIGNANI S, CAMINADE AM, SHI X. Potent anticancer efficacy of first-in-class Cu(II) and Au(III) metaled phosphorus dendrons with distinct cell death pathways. Chemistry, 2020, 26: 5903 DOI 10.1002/chem.202001014
  • PERESSE T, KOVACS D, SUBRA M, BIGAY J, TSAI MC, POLIDORI J, GAUTIER R, DESRAT S, FLEURIOT L, DEBAYLE D, LITAUDON M, PHAM VC, BIGNON J, ANTONNY B, ROUSSI F, MESMIN B. Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor. J Biol Chem., 2020 295 : 4277 DOI 10.1074/jbc.RA119.012012
  • GAPIL TS., DARESSY F., ABOU SAMRA A., BIGNON J., STEINMETZ V., LITAUDON M., FOURNEAU C., HOONG LK., ARIFFIN A., AWANG K., DESRAT S., ROUSSI F.Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2.Bioorg Med Chem Lett., 2020 Feb 3:127003DOI: 10.1016/j.bmcl.2020.127003.
  • 2019
  • ZHANG K., EL BOUAKHER A., LEVAIQUE H., BIGNON J., RETAILLEAU P., ALAMI M., HAMZE A.Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application.J Org Chem. 2019, 84(21), pp.13807-13823DOI: 10.1021/acs.joc.9b02018
  • KHELIFI I., NARET T., HAMZE A., BIGNON J., LEVAIQUE H., GARCIA ALVAREZ MC., DUBOIS J., PROVOT O., ALAMI M.N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agentsEur J Med Chem., 2019, (15), pp.168:176DOI: 10.1016/j.ejmech.2019.02.038
  • NARET T., KHELIFI I., PROVOT O., BIGNON J., LEVAIQUE H., DUBOIS J., SOUCE M., KASSELOURI A., DEROUSSENT A., PACI A., VARELA PF., GIGANT B., ALAMI M., HAMZE A.1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological EvaluationJ Med Chem., 2019, 62(4), pp.1902-1916DOI: 10.1021/acs.jmedchem.8b01386
  • 2018
  • ZHAO G., BIGNON J., LEVAIQUE H., DUBOIS J., ALAMI M., PROVOT O.One Pot Synthesis of 2-Styrylindoles from Ortho-Substituted ChloroenynesJ Org Chem. 2018, 283(24), pp.15323-15332DOI: 10.1021/acs.joc.8b02563
  • NARET T., BIGNON J., BERNADAT G., BENCHEKROUN M., LEVAIQUE H., LENOIR C., DUBOIS J., PRUVOST A., SALLER F., BORGEL D., MANOURY B., LEBLAIS V., DARRIGRAND R., APCHER S., BRION J.-D., SCHMITT E., LEROUX F. R., ALAMI M. HAMZE A. A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation Eur. J. Med. Chem., 2018, 143, pp.473-490 DOI: 10.1016/j.ejmech.2017.11.055
  • ABOU SAMRA A., ROBERT A., GOV C., FAVRE L., ELOY L., JACQUET E., BIGNON J., WIELS J., DESRAT S. ROUSSI F. Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A European Journal of Medicinal Chemistry, 2018, 148, pp.26-38 DOI: 10.1016/j.ejmech.2018.01.100
  • APEL C., BIGNON J., GARCIA-ALVAREZ M. C., CICCONE S., CLERC P., GRONDIN I., GIRARD-VALENCIENNES E., SMADJA J., LOPES P., FRÉDÉRICH M., ROUSSI F., MEINNEL T., GIGLIONE C. LITAUDON M. N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë Fitoterapia, 2018, 131: 91-95 DOI: https://DOI.org/10.1016/j.fitote.2018.10.014
  • NGUYEN T. L., NOKIN M. J., EGOROV M., TOME M., BODINEAU C., DI PRIMO C., MINDER L., WDZIECZAK-BAKALA J., GARCIA-ALVAREZ M. C., BIGNON J., THOISON O., DELPECH B., SURPATEANU G., FRAPART Y. M., PEYROT F., ABBAS K., TERES S., EVRARD S., KHATIB A. M., SOUBEYRAN P., IORGA B. I., DURAN R. V. COLLIN P. mTORInhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells. Cancer Research, 2018, 78(18), pp.5384-5397
    DOI: 10.1158/0008-5472.can-18-0232
  • LAMAA D., LIN H.-P., ZIG L., BAUVAIS C., BOLLOT G., BIGNON J., LEVAIQUE H., PAMLARD O., DUBOIS J., OUAISSI M., SOUCE M., KASSELOURI A., SALLER F., BORGEL D., JAYAT-VIGNOLES C., AL-MOUHAMMAD H., FEUILLARD J., BENIHOUD K., ALAMI M. HAMZE A. Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. J. Med. Chem., 2018, 61(15), pp.6574-6591 DOI: 10.1021/acs.jmedchem.8b00050
  • GICQUEL M., GOMEZ C., GARCIA ALVAREZ M. C., PAMLARD O., GUERINEAU V., JACQUET E., BIGNON J., VOITURIEZ A. MARINETTI A. Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3′-Spirocyclopentene Oxindole Derivatives Journal of medicinal chemistry, 2018, 61(20), pp.9386-9392 DOI: 10.1021/acs.jmedchem.8b01137

2017

  • PIGEON P., WANG Y., TOP S., NAJLAOUI F., GARCIA ALVAREZ M. C., BIGNON J., MCGLINCHEY M. J. JAOUEN G.
    A new series of succinimido-ferrociphenols and related heterocyclic species induce strong antiproliferative effects, especially against ovarian cancer cells resistant to cisplatin. J. Med. Chem., 2017, 60(20), pp.8358-8368 DOI: 10.1021/acs.jmedchem.7b00743
  • PERESSE T., JEZEQUEL G., ALLARD P.-M., PHAM V.-C., HUONG D. T. M., BLANCHARD F., BIGNON J., LEVAIQUE H., WOLFENDER J.-L., LITAUDON M. ROUSSI F. Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius. J. Nat. Prod., 2017, 80(10), pp.2684-2691 DOI: 10.1021/acs.jnatprod.7b00409
  • KHELIFI I., NARET T., RENKO D., HAMZE A., BERNADAT G., BIGNON J., LENOIR C., DUBOIS J., BRION J.-D., PROVOT O. ALAMI M. Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors. Eur. J. Med. Chem., 2017, 127(pp.1025-1034 DOI: http://dx.DOI.org/10.1016/j.ejmech.2016.11.012
  • BZEIH T., LAMAA D., FRISON G., HACHEM A., JABER N., BIGNON J., RETAILLEAU P., ALAMI M. HAMZE A. Csp2-Csp2 and Csp2-N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives Org. Lett., 2017, 19(24), pp.6700-6703 DOI: 10.1021/acs.orglett.7b03422
  • 2016
  • GHERBOVET O., GARCÍA ALVAREZ M. C., BIGNON J. ROUSSI F. Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors. J. Med. Chem. , 2016, 59(pp.10774-10780 DOI: 10.1021/acs.jmedchem.6b00525
  • GENY C., RIVIERE G., BIGNON J., BIRLIRAKIS N., GUITTET E., AWANG K., LITAUDON M., ROUSSI F. DUMONTET V. Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions. Journal of natural products, 2016, 79(4), pp.838-44 DOI: 10.1021/acs.jnatprod.5b00915
  • BZEIH T., NARET T., HACHEM A., JABER N., KHALAF A., BIGNON J., BRION J.-D., ALAMI M. HAMZE A. A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer. Chem. Commun., 2016, 52(88), pp.13027-13030 DOI: 10.1039/c6cc07666a
  • SOUSSI M. A., PROVOT O., BERNADAT G., BIGNON J., DESRAVINES D., DUBOIS J., BRION J.-D., MESSAOUDI S. ALAMI M. IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity. ChemMedChem, 2015, 10(8), pp.1392-1402 DOI: 10.1002/cmdc.201500069
  • 2015
  • ROCHE M., SALIM S. M., BIGNON J., LEVAIQUE H., BRION J.-D., ALAMI M. HAMZE A. Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives. J. Org. Chem., 2015, 80(13), pp.6715-6727 DOI: 10.1021/acs.joc.5b00880
  • RENKO D., PROVOT O., RASOLOFONJATOVO E., BIGNON J., RODRIGO J., DUBOIS J., BRION J.-D., HAMZE A. ALAMI M. Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents. Eur. J. Med. Chem., 2015, 90(0), pp.834-844 DOI: 10.1016/j.ejmech.2014.12.024
  • RABHI C., ARCILE G., CARIEL L., LENOIR C., BIGNON J., WDZIECZAK-BAKALA J. OUAZZANI J. Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants. J. Med. Food, 2015, 18(9), pp.1065-1072 DOI: 10.1089/jmf.2014.0128
  • GHERBOVET O., SANCHEZ-MURCIA P. A., GARCIA ALVAREZ M. C., BIGNON J., THORET S., GAGO F. ROUSSI F. Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin. Org. Biomol. Chem., 2015, 13(10), pp.3144-3154 DOI: 10.1039/c4ob02114b
  • GHERBOVET O., LA SPISA F., THORET S., GARCIA ALVAREZ M. C., LEVAIQUE H., BIGNON J. ROUSSI F. Synthesis and biological evaluation of C-13 ‘ substituted 7 ‘-homo-anhydrovinblastine derivatives. Bioorg. Med. Chem. Lett., 2015, 25(8), pp.1771-1773 DOI: 10.1016/j.bmcl.2015.02.045
  • CORLAY N., LECSO-BORNET M., LEBORGNE E., BLANCHARD F., CACHET X., BIGNON J., ROUSSI F., BUTEL M.-J., AWANG K. LITAUDON M. Antibacterial labdane diterpenoids from Vitex vestita. J. Nat. Prod., 2015, 78(6), pp.1348-56 DOI: 10.1021/acs.jnatprod.5b00206
  • 2014
  • TREGUIER B., LAWSON M., BERNADAT G., BIGNON J., DUBOIS J., BRION J.-D., ALAMI M. HAMZE A. Synthesis of a 3-(alpha-Styryl)benzo b -thiophene Library via Bromocyclization of Alkynes and Palladium-Catalyzed Tosylhydrazones Cross-Couplings: Evaluation as Antitubulin Agents. Acs Combinatorial Science, 2014, 16(12), pp.702-710 DOI: 10.1021/co500115b
  • SOUSSI M. A., PROVOT O., BERNADAT G., BIGNON J., WDZIECZAK-BAKALA J., DESRAVINES D., DUBOIS J., BRION J.-D., MESSAOUDI S. ALAMI M. Discovery of azaisoerianin derivatives as potential antitumors agents. European Journal of Medicinal Chemistry, 2014, 78(pp.178-189 DOI: 10.1016/j.ejmech.2014.03.032
  • ROCHE M., BIGNON J., BRION J. D., HAMZE A. ALAMI M. Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells. J. Org. Chem., 2014, 79(16), pp.7583-7592 DOI: 10.1021/jo501315q
  • JIA L., CUI D., BIGNON J., DI CICCO A., WDZIECZAK-BAKALA J., LIU J. LI M.-H. Reduction-responsive cholesterol-based block copolymer vesicles for drug delivery. Biomacromolecules, 2014, 15(6), pp.2206-2217 DOI: 10.1021/bm5003569
  • GHERBOVET O., CODERCH C., GARCIA ALVAREZ M. C., BIGNON J., THORET S., GUERITTE F., GAGO F. ROUSSI F. One-pot synthesis of vinca alkaloids-phomopsin hybrids. J. Med. Chem., 2014, 57(12), pp.5470-5476 DOI: 10.1021/jm500530v