CV E. Lescop

Nuclear Magnetic Resonance (NMR) spectroscopy provides a wealth of information about the structure and dynamics of biomolecules in solution as well as of their complexes. As such, it highly contributes to our understanding of the molecular mechanisms that underly life. Such knowledge is fundamental not only for the general quest for a better understanding of nature but is also required for rational approaches in health or agronomy industry.

My research interests lie in the development of NMR methods, in particular to speed up NMR data collection and the application of NMR to understand the role of interdomain dynamics in the catalytic cycle of the human CPR, the role of heme orientation in the function of the hexacoordinated human neuroglobin and the structural and dynamics study of microcins and the TCTP cancer drug. More recently I started a research program about protein/lipid interactions with biomembrane with a new and original approach using high-pressure NMR.

Complete list

1.  Brutscher, B., and Lescop, E. Methods Mol Biol. 2012, 831, 407-428. doi: 10.1007/978-1-61779-480-3_21.
2. Vincent, B., Morellet, N., Fatemi, F., Aigrain, L., Truan, G., Guittet, E., and Lescop, E. J Mol Biol. 2012, 420, 296-309. doi: 10.1016/j.jmb.2012.03.022
3. Bocahut, A., Derrien, V., Bernad, S., Sebban, P., Sacquin-Mora, S., Guittet, E., and Lescop, E. J Biol Inorg Chem. 2013, 18, 111-122. doi: 10.1007/s00775-012-0956-2
4. Frances, O., Fatemi, F., Pompon, D., Guittet, E., Sizun, C., Perez, J., Lescop, E., and Truan, G. Biophys J. 2015,  108, 1527-1536. doi: 10.1016/j.bpj.2015.01.032.
5. Malard F, Assrir N, Alami M, Messaoudi S, Lescop E, Ha-Duong T. J Mol Biol. 2018, 430(11), 1621-1639. doi: 10.1016/j.jmb.2018.04.024
6. Malard F, Sizun C, Thureau A, Carlier L, Lescop E. J Biol Chem. 2023 16:104830. doi: 10.1016/j.jbc.2023.104830.
7. Pozza A, Giraud F, Cece Q, Casiraghi M, Point E, Damian M, Le Bon C, Moncoq K, Banères JL, Lescop E, Catoire LJ. Nat Commun. 2022 Apr 1;13(1):1780. doi: 10.1038/s41467-022-29410-5.

• ANR UnderPressure (with L. Catoire and J.Henin/G. Stirnemann)
• ANR Mycrho (with M. Boudvillain)
• ANR Allosig, Ghredyn DynaLand (with JL Banères, L. Catoire)
• ANR Erbb2Cter and Flexiplex (with C. van Heijenoort)
• ANR Midiazone (with C. Bouton), Frataxur (with B. d’Autréaux)

• MP. Golinelli-Cohen (ICSN)
• Y. Li, S. Zirah, S. Rebuffat (MNHN, Paris)
• L. Catoire (IBPC, Paris)
• JL Banères (IBMM, Montpellier)
• J. Henin, G. Stirneman (IBPC, Paris)
• A. Chauchereau (IGR, Villejuif)
• H. Pasquier (ICP, Orsay)

since 2009 : Master Engineering and Chemistry of Biomolecules of Paris-Saclay University

since 2009 : Coordinator of the Gif-node for NMR practical wokshop Gigrill

since 2013 : Coorganizer of the Renafobis workshop Ecole d’Oléron

2010 : UNESCO Chair Ramallah (Palestine)

• Invited Professor by PROTEO network at INRS, 2017
• Elected member of the CNRS Comité National (section 16, 2012-2016)
• Active member of the Renafobis network for Integrative Structural Biology
• Representative of IR-RMN for industrial affairs
• Coordinator of the CBSA department at ICSN